11526例中老年人血压、吸烟、体重指数与全死因的8年随访COX回归分析

目的探讨广西40岁以上人群全死因构成比及影响因素。方法在1991年全国高血压调查的基础上,对广西40岁以上的11 526人进行随访调查,到死亡者死亡时所在医院核实死因,取得其全死因资料。结果死因顺位1~6位的疾病分别是脑卒中、肺部疾病、癌症、原因不明的死亡、心肌梗塞及消化性疾病。全死因COX回归分析表明,舒张压每增高1 mmHg,总的死亡相对危险度增加0.01;收缩压增高未对总死因产生影响;吸烟者的总的死亡相对危险度是不吸烟者的1.48倍;有心肌梗塞史者的总死亡相对危险度是无心肌梗塞者的3.11倍;有脑卒中史者的总死亡相对危险度是无脑卒中史者的1.95倍;男性比女性的总死亡发生率高。各死亡原因的COX回归分析表明,血压升高增加脑卒中、冠心病、癌症和糖尿病的相对死亡危险;吸烟增加冠心病、脑卒中、呼吸性疾病、癌症死亡的相对危险;体重指数升高增加脑卒中、冠心病及癌症死亡的相对危险。结论高血压、吸烟、有心肌梗塞及脑卒中史、男性人群是中老年人总死亡的危险因素。

Cox regression analysis of affected factors of all-cause mortality in 11 526 dults over 40 years old 8 years follow-up study in Guangxi province, China

Objective To explore the affected factors of all-cause mortality in adult over 40 years old in Guangxi province,China.Methods Baseline data was based on The Third National Blood Pressure Survey in 1991 in China.11 526 adults over 40 years old had been followed up for survey to collect the data of all-cause mortality.Results Cox regression analysis for all-cause mortality showed that the incidence of total mortality increased by 0.01 when diastolic blood pressure increased by 1 mmHg,systolic blood pressure did not affect total mortality.There was 1.48 times higher in smoker than non-smoker in the relative risks(RRs) for total mortality.RRs for total mortality were 3.11 for those who had a myocardial infarction history and 1.95 for those who had a stroke history.Man's total mortality was higher than woman's.Cox regression analysis for all-cause mortality showed that the increase of blood pressure increased the mortality of stroke,coronary heart disease,cancer and diabetes.Cigarette smoking increased the mortality of stroke,coronary heart disease,cancer and respiratory disease;high body mass index(BMI) increased the mortality of stroke,coronary heart disease and cancer.Conclusion Hypertension,smoking,history of myocardial infarction and stroke,male people are the risk factors of total mortality in adults over 40 years old.