Late-onset self-healing reticulohistiocytosis: pediatric case of Hashimoto-Pritzker type Langerhans cell histiocytosis |
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Authors: | Nakahigashi Kyoko Ohta Miyuki Sakai Rie Sugimoto Yasushi Ikoma Yukiko Horiguchi Yuji |
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Affiliation: | Department of Dermatology, Osaka Red Cross Hospital, Ten'noji-ku, Osaka, Japan. |
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Abstract: | An 8-year-old otherwise healthy girl presented with a 3-month history of multiple asymptomatic, reddish-brown papules over the face and upper limbs. Histopathological and immunohistochemical examinations demonstrated an infiltrate of mononuclear cells containing abundant histiocytic cells in the dermis, and microabscess-like accumulation of the histiocytic cells in the epidermis. The histiocytic cells were positive for antibodies against S-100 protein and CD1a, but negative for anti-CD68. Lag and anti-langerin monoclonal antibodies reacted more weakly with these histiocytic cells than with Langerhans cells in the surrounding epidermis. The skin lesions spontaneously regressed within the following 3 months, and neither systemic involvement nor local recurrence was observed during the next 10 months. This case should be categorized as congenital self-healing reticulohistiocytosis (Hashimoto-Pritzker), although the onset was not early in life. |
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Keywords: | congenital self-healing reticulohistiocytosis histiocytosis Langerhans cell |
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