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| HLA-A、DRB1等位基因多态性与上海汉族人乙肝后肝硬化相关性研究 | |
| 引用本文： | 陈兰羽,陈建杰,章晓鹰. HLA-A、DRB1等位基因多态性与上海汉族人乙肝后肝硬化相关性研究[J]. 胃肠病学和肝病学杂志, 2005, 14(5): 487-489 |
| 作者姓名： | 陈兰羽 陈建杰 章晓鹰 |
| 作者单位： | 1. 中国中医研究院广安门医院消化科,北京,100053 2. 上海中医药大学附属曙光医院肝炎科 3. 上海中医药大学附属曙光医院检验科 |
| 摘 要： | 目的探讨HLAA、DRB1位点等位基因多态性与上海地区汉族人乙肝后肝硬化的相关性。方法采用基因芯片分型方法,检测61例乙型肝炎后肝硬化患者HLAA、DRB1分型,并与146例正常人的结果进行比较。结果HLAA02及HLADRB107、HLADRB108、HLADRB111的频率在乙肝后肝硬化组明显升高,与正常组比较差异显著。其它等位基因频率在实验组和对照组无显著性差异。结论HLAA02及HLADRB107、HLADRB108、HLADRB111与上海汉族人乙肝后肝硬化的发生明显相关。 |
| 关 键 词： | 乙肝后肝硬化 HLA 基因芯片 |
| 文章编号： | 1006-5709（2005）05-0487-03 |
| 收稿时间： | 2005-03-20 |
| 修稿时间： | 2005-03-20 |
Study on the association between HLA-A, DRB1 alleles and posthepatitis B-cirrhosis in shanghai han''''s population |
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| CHEN Lanyu,CHEN Jianjie,ZHANG Xiaoying. Study on the association between HLA-A, DRB1 alleles and posthepatitis B-cirrhosis in shanghai han''''s population[J]. Chinese Journal of Gastroenterology and Hepatology, 2005, 14(5): 487-489 | |
| Authors: | CHEN Lanyu CHEN Jianjie ZHANG Xiaoying |
| Abstract: | Objective To explore the relationship between HLA-A, DRB1 alleles and posthepatitis B-cirrhosis in Shanghai ban's population. Methods HLA-A, DRB1 genotyping were determined in 61 patients with posthepatitis B-cirrhosis and 146 healthy controls by DNA chips. Results The frequency of HLA-A02 and HLA-DRB1*07, HLA_DRB1*08, HLA_DRB1*11 alleles in the posthepatitis B_cirrhosis group were higher than those in the normal group. No different allele frequencies of other alleles were observed between the posthepatitis B_cirrhosis group and the normal control group.Conclusion HLA_A02 and HLA_DRB1*07,HLA_DRB1*08, HLA_DRB1*11 alleles are closely associated with the susceptibility to posthepatitis B_cirrhosis in shanghai ban's population. |
| Keywords: | Posthepatitis B cirrhosis HLA genotyping DNA chip |
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