| 血小板活化因子受体在闭合性颅脑损伤中的表达 |
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| 引用本文： | 李志强,张永亮,李灵芝,舒清明. 血小板活化因子受体在闭合性颅脑损伤中的表达[J]. 武警医学, 2008, 19(1): 20-23 |
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| 作者姓名： | 李志强 张永亮 李灵芝 舒清明 |
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| 作者单位： | 武警内蒙古总队医院内二科,呼和浩特,010031;武警医学院,科研部,天津,300162;武警医学院,药化教研室,天津,300162;武警总医院病理科,北京,100039 |
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| 摘 要： | 目的 研究闭合性脑损伤后PAF-R在脑组织中的表达部位、时序性特点.方法 采用免疫组化SP法检测脑损伤后不同时间SD大鼠脑组织PAF-R的表达情况.结果 脑损伤后,PAF-R表达在1～2 h开始减少,1 2～24 h达最低值,7 d时仍低于正常.顶叶皮层、胼胝体阳性细胞面积、阳性细胞计数与对照组比较差别有统计学意义(P＜0.01).结论 PAF-R参与了闭合性颅脑损伤的病理过程.
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| 关 键 词： | 闭合性颅脑损伤 血小板活化因子受体 |
| 收稿时间： | 2007-05-25 |
| 修稿时间： | 2007-05-25 |
Expression of platelet activating factor receptor gene following Brain Injury in Rats |
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| LI Zhiqiang,ZHANG Yongliang,LI Lingzhi,SHU Qingming. Expression of platelet activating factor receptor gene following Brain Injury in Rats[J]. Medical Journal of the Chinese People's Armed Police Forces, 2008, 19(1): 20-23 |
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| Authors: | LI Zhiqiang ZHANG Yongliang LI Lingzhi SHU Qingming |
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| Affiliation: | LI Zhiqiang, ZHANG Yongliang, LI Lingzhi, and SHU Qingming. (Second Department of Internal Medicine, Inner Mongolian Autonomous Regional Corps Hospital, Chinese People＇s Armed Pohce Forces, Huhhot 010031, China) |
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| Abstract: | Objective To study the temporal patterns of platelet activating factor receptor（PAF - R） after closed traumatic brain injury （TBI） in rats. Methods The expression of PAF- R was studied by immunohistochemistry in the brain of Sprague- Dawley rats. Results One hour after closed traumatic brain injury, the expression of PAF - R in brain tissue decreased progressively, roached the nadir after 12 - 24 h, and was still lower than the normal after 7 d. The number and area of PAF - R positive neurons increased progressively in parietal cortex, corpus callosum, compared with sham operation control （ P 〈 0.01）. Conclusions PAF- R is involved in the pathology after closed traumatic brain injury. |
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| Keywords: | Traumatic brain injury Platelet activating factor receptor |
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