Chromosomal abnormalities in patients with oligozoospermia and non-obstructive azoospermia |
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Authors: | Larysa Y. Pylyp Lyudmyla O. Spinenko Natalia V. Verhoglyad Valery D. Zukin |
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Affiliation: | 1. Clinic of Reproductive Medicine “Nadiya”, M. Kryvonosa St. 19a, Kyiv, 03037, Ukraine
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Abstract: | PurposeTo assess the frequency and types of chromosomal abnormalities in 204 Ukrainian patients with non-obstructive azoospermia and oligozoospermia and 87 men with normozoospermia.MethodsCytogenetic studies were performed on peripheral blood lymphocyte samples of 164 men with oligozoospermia, 40 men with non-obstructive azoospermia and 87 men with normozoospermia attending infertility clinic.ResultsChromosomal abnormalities were detected in 17 % of patients with sperm disorders: in 35 % of men with azoospermia and in 12.7 % of men with oligozoospermia. The frequency of chromosomal abnormalities in patients with sperm disorders was significantly higher, than in patients with normozoospermia (P = 0.0001). An increase in the incidence of chromosomal abnormalities with the decrease of sperm count was observed. Chromosomal abnormalities were detected in 1.1 % of patients with normozoospermia, 6.5 % of patients with mild oligozoospermia (sperm count 5–15 × 106/ml), 18.4 % of patients with severe oligozoospermia (sperm count <5 × 106/ml) and 35 % of patients with azoospermia. A significant increase in the frequency of chromosomal abnormalities in patients with severe oligozoospermia was observed when compared to mild oligozoospermia (P = 0.01). A statistically significant association (P = 0.02) of chromosomal abnormalities and sex chromosome abnormalities (P = 0.0001) with azoospermia when compared to oligozoospermia was observed.ConclusionsOur results highlight the importance of cytogenetic studies in patients with oligozoospermia (both mild and severe) and non-obstructive azoospermia. The presence of chromosomal abnormalities influences significantly the fertility treatment protocols, as well as provides a definite diagnosis to couples suffering from infertility. |
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Keywords: | Male infertility Azoospermia Oligozoospermia Chromosomal abnormalities |
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