Association between the GSTP1 Ile105Val polymorphism and prostate cancer risk: a systematic review and meta-analysis |
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Authors: | Zhuo Yu Zhong Li Bing Cai Ziming Wang Weimin Gan Haiwen Chen Hecheng Li Peng Zhang Hongliang Li |
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Institution: | 1. Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China 2. Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, Tianjin, 300211, China 3. Department of Urology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, 32500, China 4. Department of Urology, The Second Affiliated Hospital, Xi’an Jiaotong University, Xi’an, 710004, China
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Abstract: | Many studies have reported the role of glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism with prostate cancer (PCa) risk. However, these studies have yielded conflicting results. Hence, we performed this meta-analysis to investigate the association between GSTP1 Ile105Val polymorphism and PCa in different inheritance models. A total of 13 eligible studies were pooled into this meta-analysis. There was significant association between the GSTP1 Ile158Val variant genotypes and PCa for Ile/Ile vs Val/Val comparison odds ratio (OR)?=?0.705; I 2?=?63.7 %; 95 % confidence interval (95 % CI)?=?0.508–0.977], Ile/Val vs Val/Val comparison (OR?=?0.736; I 2?=?8.0 %; 95 % CI?=?0.613–0.883), and dominant model (OR?=?0.712; I 2?=?45.5 %; 95 % CI?=?0.555–0.913). However, no associations were detected for other genetic models. In the stratified analysis by ethnicity, significant associations between GSTP1 Ile105Val polymorphism and PCa risk were also found among Caucasians (Ile/Ile vs Val/Val comparison OR?=?0.818, I 2?=?0.0 %, 95 % CI?=?0.681–0.982; Ile/Val vs Val/Val comparison OR?=?0.779, I 2?=?0.0 %, 95 % CI?=?0.651–0.933; and dominant model OR?=?0.794, I 2?=?0.0 %, 95 % CI?=?0.670–0.941), while there were no associations found for other genetic models. However, no associations were found in Asians and African-Americans for all genetic models when stratified by ethnicity. In conclusion, our meta-analysis indicates that GSTP1 Ile105Val polymorphisms contributed to the PCa susceptibility. However, a study with the larger sample size is needed to further evaluate gene–environment interaction on GSTP1 Ile105Val polymorphisms and PCa risk. |
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