Biological monitoring of occupational exposure to cyclohexane by urinary 1,2- and 1,4-cyclohexanediol determination |
| |
| Authors: | A Perico C Cassinelli F Brugnone P Bavazzano L Perbellini |
| |
| Institution: | (1) Unità Operativa Tossicologica Occupazionale, Azienda Sanitaria di Firenze, Florence, Italy, IT;(2) Sezione di Igiene Industriale, Azienda Sanitaria di Firenze, Florence, Italy, IT;(3) Institute of Occupational Medicine, University of Verona, Verona, Italy, IT;(4) Istituto di Medicina del Lavoro, Policlinico Borgo Roma, I-37134 Verona, Italy, IT |
| |
| Abstract: | Objectives: This article reports the results obtained with the biological and environmental monitoring of occupational exposure to cyclohexane
using 1,2-cyclohexanediol (1,2-DIOL) and 1,4-DIOL in urine. The kinetic profile of 1,2-DIOL in urine suggested by a physiologically
based pharmacokinetic (PBPK) model was compared with the results obtained in workers. Methods: Individual exposure to cyclohexane was measured in 156 workers employed in shoe and leather factories. The biological monitoring
of cyclohexane exposure was done by measurement of 1,2-DIOL and 1,4-DIOL in urine collected on different days of the working
week. In all, 29 workers provided urine samples on Monday (before and after the work shift) and 47 workers provided biological
samples on Thursday at the end of the shift and on Friday morning. Another 86 workers provided biological samples at the end
of the work shift only on Monday or Thursday. Results: Individual exposure to cyclohexane ranged from 7 to 617 mg/m3 (geometric mean value 60 mg/m3). Urinary concentrations of 1,2-DIOL (geometric mean) were 3.1, 7.6, 13.2, and 6.3 mg/g creatinine on Monday (pre- and postshift),
Thursday (postshift) and Friday (pre-shift), respectively. The corresponding values recorded for 1,4-DIOL were 2.8, 5.1, 7.8,
and 3.7 mg/g creatinine. A fairly close, statistically significant correlation was found between environmental exposure to
cyclohexane and postshift urinary 1,2-DIOL and 1,4-DIOL on Monday. Data collected on Thursday and Friday showed only a poor
correlation to exposure with a wide scatter. Both metabolites have a urinary half-life of close to 18 h and accumulate during
the working week. Conclusions: Comparison between data obtained from a PBPK model and those found in workers suggests that 1,2-DIOL and 1,4-DIOL are urinary
metabolites suitable for the biological monitoring of industrial exposure to cyclohexane.
Received: 17 June 1998 / Accepted: 23 September 1998 |
| |
| Keywords: | Cyclohexane Biological monitoring 1 2-Cyclohexanediol 1 4-Cyclohexanediol |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
