Visceral adipose tissue is more strongly associated with insulin resistance than subcutaneous adipose tissue in Chinese subjects with pre-diabetes |
| |
| Authors: | Lin Liu Jitao Feng Gong Zhang Xiaodan Yuan Fan Li Tingting Yang |
| |
| Institution: | 1. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, PR China;2. Seven OAKS General Hospital, Winnipeg, Canada;3. Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, PR China |
| |
| Abstract: | Aims: To investigate the value of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) in a cohort of a community’s residents who were diagnosed as pre-diabetes, and to evaluate the association of VAT and SAT with insulin resistance.Methods: This study was based on cross-sectional analysis of data from 107 adults. VAT and SAT were assessed by computed tomography. Insulin resistance was defined by homeostasis model assessment of insulin resistance >2.69. The relationship of VAT and SAT with insulin resistance were examined by linear regression. Logistic regression was used to analyze the association of VAT and SAT with insulin resistance.Results: A total of 87 subjects had VAT ≥100?cm2. Thirty-six out of 107 (33.6%) subjects were detected to have insulin resistance, 71 were normal (66.4%), and all had insulin resistance with VAT ≥100?cm2. VAT (r?=?0.378, p?r?=?0.357, p?p?=?.003), but that of SAT was lost.Conclusion: Pre-diabetic subjects with insulin resistance had elevated levels of VAT. VAT was more strongly associated with insulin resistance than SAT in Chinese subjects with pre-diabetes. |
| |
| Keywords: | Pre-diabetes visceral adipose tissue insulin resistance subcutaneous adipose tissue |
|
|
