| Mutation in the NS5A Region of Chinese HCV-1b Isolates and Its Correlation with Efficacy of Interferon Alpha Therapy |
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| 引用本文： | Zhang Yongxiang(张永祥) Sun Nanxiong(孙南雄) Huang Zuhu(黄祖瑚) Han Yaping(韩亚萍) Liu Ting(刘 婷) Research Laboratory of Infectious Diseases,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,P. R. China. Mutation in the NS5A Region of Chinese HCV-1b Isolates and Its Correlation with Efficacy of Interferon Alpha Therapy[J]. 南京医科大学学报(英文版), 2000, 0(1) |
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| 作者姓名： | Zhang Yongxiang(张永祥) Sun Nanxiong(孙南雄) Huang Zuhu(黄祖瑚) Han Yaping(韩亚萍) Liu Ting(刘 婷) Research Laboratory of Infectious Diseases the First Affiliated Hospital of Nanjing Medical University Nanjing 210029 P. R. China |
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| 作者单位： | Zhang Yongxiang(张永祥) Sun Nanxiong(孙南雄) Huang Zuhu(黄祖瑚) Han Yaping(韩亚萍) Liu Ting(刘 婷) Research Laboratory of Infectious Diseases，the First Affiliated Hospital of Nanjing Medical University，Nanjing 210029，P. R. China |
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| 基金项目： | This project was supported by research fund from Department of Health and Department of Personal Jiangsu Province! 2 76EC960 6 |
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| 摘 要： | Interferonalpha(IFN-α)hasbeenprovenaneffectivetherapeuticdrugforchronichepatitisCvirus(HCV)infection.However,therateofresponsetoIFN-αtherapyisquitelow,andisevenloweramongthepatientswithHCV1binfection[1].Enomotoetal[2]noticedthatHCVRNApersistedinserumduringtherapyinpatientswithHCV1binfectionthatdidnotrespondtoIFN-α,butthatthedistributionofHCVquasispecieschanged.So,theyhypothesizedthatIFN-αtherapywouldleadtoclearanceoftheinterferon-sensitivequasispeciesleavingbehindtheresistanton…
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Mutation in the NS5A Region of Chinese HCV 1b Isolates and Its Correlation with Efficacy of Interferon Alpha Therapy |
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| Zhang Yongxiang. Mutation in the NS5A Region of Chinese HCV 1b Isolates and Its Correlation with Efficacy of Interferon Alpha Therapy[J]. Journal of Nanjing Medical University, 2000, 0(1) |
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| Authors: | Zhang Yongxiang |
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| Abstract: | |
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| Keywords: | hepatitis C virus interferon alpha NS5A 2209 2248 genotypes |
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