Genetic polymorphism in RANK is associated with mandibular size |
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| Authors: | Erika Calvano Küchler Mariele Andrade do Nascimento Mirian Aiko Nakane Matsumoto Fabio Lourenço Romano Raquel Assed Bezerra da Silva Marjorie Ayumi Omori |
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| Affiliation: | 1. Department of Pediatric Dentistry, School of Dentistry of Ribeir?oPreto, University of S?o Paulo, Ribeir?oPreto, Brazilerikacalvano@gmail.com;3. Department of Pediatric Dentistry, School of Dentistry of Ribeir?oPreto, University of S?o Paulo, Ribeir?oPreto, Brazil;4. Department of Pediatric Dentistry, Orthodontic Clinic, School of Dentistry of Ribeir?oPreto, University of S?o Paulo, Ribeir?oPreto, Brazil |
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| Abstract: | Objective: The aim of this study was to evaluate the association between genetic polymorphisms in RANK, RANKL and OPG with maxillary and mandibular dimensions in humans.Design: DNA extracted from saliva and the rs3826620, rs9594738 and rs2073618 polymorphisms in RANK, RANKL and OPG, respectively, were analysed by real-time PCR. Four linear measurements (Co-Gn, GoPg, Co-Go and PTM–A) from lateral cephalograms were examined for the evaluation of craniofacial measurements. ANOVA testing and a multivariate linear regression analysis, adjusted for age and gender, were used for statistical analysis, with an alpha of 5%. Hardy-Weinberg equilibrium was also evaluated using the chi-square test within each polymorphism.Setting: School of Dentistry of Ribeirão Preto, University of São Paulo.Participants: A total of 100 unrelated non-syndromic Brazilian Caucasian subjects were included in this study.Results: The polymorphism in RANK was associated with a higher Go-Pg measurement (p?=?.039). In the multivariate analysis, adjusted for age and gender, the polymorphism in RANK was associated with Go-Pg (p?=?.017) and Co-Gn (p?=?.043).Conclusion: The polymorphism rs3826620 in RANK is associated with the mandibular size. |
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| Keywords: | Gene polymorphisms mandible and maxilla |
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