Butyrylcholinesterase activity and mortality risk in hemodialysis patients: Comparison to hsCRP and albumin |
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| Authors: | Marina D Stojanov Dušanka M Jovičić Stevan P Djurić Marija M Konjević Zoran M Todorović Milica Š Prostran |
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| Institution: | 1. Institute of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, PO Box 146, 11000 Belgrade, Serbia;2. Clinical Chemical Laboratory, General Hospital, Pan?evo, Serbia;3. Department of Hemodialysis, General Hospital, Pan?evo, Serbia;4. Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, Belgrade, University of Belgrade, Serbia;1. Department of Minimally Invasive Surgery, Bariatric and Metabolic Institute, M61, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA;2. Department of Bariatric Surgery, St. Mary''s Duluth Clinic, Duluth, MN, USA;1. Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China;2. Department of Hepatobiliary Surgery of the First Affiliated Hospital of Anhui Medical University, Hefei, China;3. Department of Hepatobiliary Surgery of the Second Affiliated Hospital of Anhui Medical University, Hefei, China;4. Department of Laboratory Center of the First Affiliated Hospital of Anhui Medical University, Hefei, China;1. Department of Surgery, Stanford School of Medicine, Stanford University, Stanford, California;2. Department of Medicine, Stanford School of Medicine, Stanford University, Stanford, California |
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| Abstract: | ObjectiveTo test the prediction power of butyrylcholinesterase (BuChE) activity for mortality risk in hemodialysis patients during 12 months follow-up, and made comparison to hsCRP and albumin.Materials and methodsThe study enrolled 62 patients, aged 31–79 years. Serum BuChE, high-sensitivity C-reactive protein (hsCRP) and albumin were measured after 1, 3, 9 and 12 months of dialysis. The Kaplan–Meier survival curves were employed in mortality prediction.ResultsBuChE was positively associated with serum albumin (r = 0.318; p = 0.012) and inversely related to hsCRP (r = ? 0.358; p = 0.004). The highest mortality was in the lowest quartile of basal albumin (< 38.4 g/L; p = 0.027), hsCRP concentrations > 8 mg/L (p = 0.005), and BuChE activity in the lowest tercile of basal values (< 5.92 kU/L; p = 0.0041).ConclusionOur results suggest that low BuChE activity may be a nonspecific risk factor for mortality in patients who are on hemodialysis. |
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