基于巨噬细胞极化探讨寒热并用法治疗溃疡性结肠炎的作用机制

巨噬细胞作为机体重要的免疫细胞在溃疡性结肠炎中发挥关键作用.巨噬细胞极化是其根据周围环境转变不同表型的动态过程,一般分为两个表型:经典激活的M1型巨噬细胞和替代激活的M2型巨噬细胞.当巨噬细胞极化为M1型时,炎症反应启动,介导组织损伤;当巨噬细胞极化为M2型时,发挥抗炎、修复组织损伤作用.在一定条件下,二者状态可以相互...

Study on the Mechanism of Combination of Cold and Heat Method in the Treatment of Ulcerative Colitis Based on Macrophage Polarization

As an important immune cell,macrophages play a key role in ulcerative colitis(UC).Macrophage polarization is a dynamic process of changing different phenotypes according to the surrounding environment.It can be divided into two phenotypes:classical activated M1 macrophage and alternative activated M2 macrophage.When macrophages polarize to M1 type,inflammation starts and mediates tissue damage;when macrophages polarize to M2 type,they play the role of anti-inflammatory and repair tissue damage.Under certain conditions,the two states can transform each other,so the different polarization phenotypes of macrophages are the"wind vane"of the development and outcome of inflammation,and regulating the polarization state of macrophages is undoubtedly the top priority in the treatment of UC.The basic pathogenesis of UC is deficiency in origin and excess in superficiality,mixed cold and heat.Therefore,in the treatment of UC,it is necessary to treat cold and heat together,regulate qi and regulate yin and yang,and Banxia Xiexin Decoction and Wumei Pill can be used.Banxia Xiexin Decoction may reduce the inflammatory reaction by inhibiting macrophage polarization to M1 type;Wumei Pill can not only reduce M1 pro-inflammatory macrophages,but also increase the expression of M2 anti-inflammatory macrophages,and restore the balance of pro-inflammatory/anti-inflammatory axis.It is a feasible way to treat UC by regulating the dynamic balance of macrophage polarization through the combination of cold and heat method in Chinese medicine.