Oxidant and antioxidant of arylesterase and paraoxonase as biomarkers in patients with hepatitis C virus |
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| Authors: | Ehab MM Ali Hanan Hussien Shehata Randa Ali-Labib Lamia M Esmail Zahra |
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| Institution: | 1. Institute of Experimental Physiology (IFISE-CONICET), Suipacha 570, 2000 Rosario, Argentina;2. University of Connecticut, School of Pharmacy, Department of Pharmaceutical Sciences, Storrs, CT, USA;3. Institute of Pharmacological Investigations (ININFA-CONICET), University of Buenos Aires, Buenos Aires, Argentina;4. Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany;1. The Cardiovascular Center, The First Hospital of Jilin University, Changchun 130021, China;2. Department of Epidemiology and Biostatistics, School of Public Health of Jilin University, Changchun 130021, China;3. The General Hospital of Jilin Chemical Group Corporation, Jilin 132022, China;1. Grenoble Alpes University Hospital, Orthogeriatric Unit, Geriatric Department, Grenoble Alpes University, GREPI UGA-EFS EA7408, Boulevard de la Chantourne, 38043 Grenoble Cedex 1, France;2. Grenoble Alpes University Hospital, Acute Geriatric Medicine Unit, Geriatric Department, Grenoble Alpes University, GREPI UGA-EFS EA7408, Boulevard de la Chantourne, 38043 Grenoble Cedex 1, France;3. Grenoble Alpes University Hospital, Rheumatology Department, Hopital Sud, GREPI UGA-EFS EA7408, 19 avenue de Kimberley, 38130 Echirolles, France;4. Institut Gustave Roussy, UMR 8200 CNRS “Stabilité génétique et Oncogenèse”, 114 rue Edouard Vaillant, 94805 Villejuif Cedex, France;5. Grenoble Alpes University Hospital, Biology Department, Grenoble Alpes University, GREPI UGA-EFS EA7408, Boulevard de la Chantourne, 38043 Grenoble Cedex 1, France |
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| Abstract: | ObjectivesOxidative stress plays a role in the pathogenesis in patients with HCV infection. The objective of this study was to evaluate oxidant and antioxidant biomarkers in patients with HCV.Design and methodsSerum malonaldehyde (MDA) and nitric oxide (NO) levels and the activities of myeloperoxidase (MPO), arylesterase (AE) and paraoxonase-1 (PON1) were determined in 23 chronic and 21 cirrhotic patients with HCV and 21 healthy subjects.ResultsCirrhotic patients with HCV had higher serum NO level and MPO activity while lower AE and PON1 activities than the chronic. Significant inverse correlation was observed between MDA and PON1 activity in patients with HCV. The most significant HCV biomarker was MDA, AE, NO and PON1. The best combined ones for sensitivity, specificity were MDA + albumin, PON1 + AST, and PON1 + albumin.ConclusionsThe use of the MDA, MPO, AE, NO and PON1 as biomarkers might be useful tools, helping in the monitoring of patients with HCV. |
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