Muscle power and physical activity are associated with bone strength in older men: The osteoporotic fractures in men study |
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| Authors: | Julie M. Cousins Moira A. Petit Misti L. Paudel Brent C. Taylor Julie M. Hughes Jane A. Cauley Joseph M. Zmuda Peggy M. Cawthon Kristine E. Ensrud |
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| Affiliation: | 1. MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton SO16 6YD, UK;2. Paediatric Endocrinology, Southampton University Hospitals NHS Foundation Trust, Southampton SO16 6YD, UK;3. NIHR Southampton Biomedical Research Centre, University of Southampton, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton SO16 6YD, UK;4. NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford OX3 7LD, UK;1. Department of Kinesiology, University of Waterloo, Waterloo, ON, Canada;2. Joint Department of Medical Imaging, Toronto General Research Institute, University Health Network, Toronto, ON, Canada;3. Centre of Excellence in Skeletal Health Assessment, Toronto General Research Institute, University Health Network, Toronto, ON, Canada;4. Arthritis Program, Toronto General Research Institute, University Health Network, Toronto, ON, Canada;5. Lyndhurst Centre, Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada;6. Department of Medicine, University of Toronto, Toronto, ON, Canada;7. Department of Medicine, McMaster University, Hamilton, ON, Canada;8. Schlegel Research Institute for Aging, University of Waterloo, Waterloo, ON, Canada;1. Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia;2. Menzies Health Institute Queensland, School of Allied Health Sciences, Griffith University, Gold Coast, Australia |
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| Abstract: | The purpose of these analyses was to explore whether physical activity score, leg power or grip strength were associated with tibia and radius estimates of bone strength, cortical density, or total bone area. Peripheral quantitative computed tomography (pQCT) was used to compare tibial and radial bone volumetric density (vBMD, mg/cm3), total (ToA, mm2) and cortical (CoA, mm2) bone area, and estimates of bone compressive strength (bone strength index, BSI) and bending strength (polar strength strain index, SSIp) in a subset (n = 1171) of men (≥ 65 years) who participated in the multi-site Osteoporotic Fractures in Men (MrOS) study. Physical activity was assessed by questionnaire (PASE), leg power by Nottingham Power Rig, and grip strength by a hand-held Dynamometer. Participants were categorized into quartiles of PASE, grip strength or leg power. The model was adjusted for age, race, clinic, weight, and limb length. In the tibia, BSI (+ 7%) and SSIp (+ 4%) were highest in the most active physically quartile compared to the least active (p < 0.05). At the 4% site of the tibia, men with the greatest leg power had both greater ToA (+ 5%, p < 0.001) and BSI (+ 5.3%, p = 0.086) compared to men with the least leg power. At the 66% site of the tibia, the men with the highest leg power, compared to the men with the lowest leg power, had greater ToA (+ 3%, p = 0.045) SSIp (+ 5%, p = 0.008). Similar results were found at both the distal and midshaft of the radius. The findings of this study suggest the importance of maintaining levels of physical activity and muscle strength in older men to prevent bone fragility. |
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