奥雷丁堡血清型沙门菌感染的临床特征与耐药性分析

目的分析奥雷丁堡血清型沙门菌感染的临床特征与耐药性,指导临床合理用药。方法收集2019年佛山地区住院患者沙门菌感染的临床分离株,对血清型,耐药性及感染者临床特征进行分析。结果2019年佛山地区共检出奥雷丁堡血清型沙门菌感染者46例,主要在7~12月秋冬季节检出。感染人群集中在≤1岁幼儿,感染症状以发热腹泻为主。针对奥雷丁堡血清型沙门菌的感染,儿童腹泻推荐第四代头孢吡肟(敏感率91.1%)。除大便标本外,其他标本类型分离出的菌株表现为敏感菌株,推荐第三代头孢头孢他啶(敏感率100%)或头孢曲松(敏感率100%)。结论奥雷丁堡血清型沙门菌主要从儿童大便标本中分离出,整体上大便分离株对所检测抗菌药物的耐药率高于其他标本类型分离株。对于临床分离奥雷丁堡血清型沙门菌,临床应根据药敏结果和患者实际情况合理规范使用抗菌药物并加强耐药监测。

Clinical Characteristics and Drug Resistance of Salmonella Serotype in Oranienburg

Objective Analyze the clinical characteristics and drug resistance of Salmonella serotype Oranienburg infection,and guide the clinical rational use of drugs.Methods The clinical isolates of Salmonella infection in hospitalized patients in Foshan in 2019 were collected,and the serotype,drug resistance and clinical characteristics of the infected were analyzed.Results A total of 46 cases of Salmonella serotypes infected with Oranienburg were detected in Foshan in 2019,mainly in the autumn and winter from July to December.The infected population was concentrated in children≤1 year old.The symptoms of infection were mainly fever and diarrhea.For the infection of Salmonella serotype of Oranienburg,the fourth-generation cefepime(sensitivity rate 91.1%)was recommended for children with diarrhea.Except for stool specimens,strains isolated from other specimen types were susceptible,and third-generation ceftazidime(sensitivity rate 100%)or ceftriaxone(sensitivity rate 100%)were recommended.Conclusion Salmonella serotype Oranienburg was mainly isolated from stool specimens of children,and the rate of resistance of stool isolates to the tested antibacterial drugs was higher than that of other specimen types.For the clinical isolation of Salmonella serotype Oranienburg,the clinical application of antibiotics should be rationally regulated and drug resistance monitoring should be strengthened according to the drug sensitivity results and the actual situation of the patient.