Pain management in mice using methanol extracts of three plants belongs to family Amaranthaceae |
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| Authors: | BS Ashok Kumar K Lakshman KN Jayaveera C Vel Murgan PA Arun Kumar R Vinod Kumar Hegade Meghda SM Sridhar |
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| Affiliation: | 1. Department of Pharmacognosy, Sri K.V. College of Pharmacy, Chickballapur, Karnataka-562101, India;2. Department of Pharmacognosy, PES College of Pharmacy, Bangalore, Karnataka, India;3. Department of Chemistry, Jawaharlal Nehru Technological University of College of Engineering, Anantapur, Andhra Pradesh, India;4. Department of Pharmacology, Sri K.V. College of Pharmacy, Chickballapur, Karnataka-562101, India |
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| Abstract: | ObjectiveTo investigate the analgesic activity of methanolic extract of Amaranthus viridis (A. viridis), Amaranthus caudatus (A. caudatus) and Amaranthus spinosus (A. spinosus).MethodsIn this study, the analgesic activity of methanol extracts of all three plants at doses of 200 and 400 mg/kg were investigated by acetic acid-induced writhings test, hot plate test and tail immersion test for mice.ResultsIt was found that all the three plants showed significant pain management effect (P<0.01) at a dose of 400 mg/kg, but showed a less significant effect at a dose of 20 mg/kg in the entire tests used for evaluation of analgesic activities (P<0.05).ConclusionsMethanol extracts of A. viridis, A. caudatus and A. spinosus show potent analgesic activities, and this study provides the scientific proof for their traditional claims. |
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