| Nrf2激动剂t-BHQ在预防术后腹腔粘连形成中的价值及其可能的机制 |
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| 引用本文： | 吴云桦,杨妮,王星傑,吴蔚童,王子君,王曙逢,李徐奇,魏光兵. Nrf2激动剂t-BHQ在预防术后腹腔粘连形成中的价值及其可能的机制[J]. 临床医学研究与实践, 2021, 6(13): 1-3,15 |
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| 作者姓名： | 吴云桦 杨妮 王星傑 吴蔚童 王子君 王曙逢 李徐奇 魏光兵 |
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| 作者单位： | 陕西省人民医院普外二科,陕西 西安,710068;西安交通大学第一附属医院普通外科,陕西 西安,710061 |
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| 基金项目： | 国家自然科学基金面上项目(No.81770521);陕西省重点研发计划一般项目-社会发展领域(No.2019SF-052)。 |
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| 摘 要： | 目的 探究Nrf2激动剂t-BHQ在预防术后腹腔粘连形成中的价值及其可能的机制.方法 将40只SD大鼠随机分为Sham组(仅行开关腹手术)、Control组(行腹腔粘连造模)、HA组(行腹腔粘连造模,关腹前在粘连部位均匀涂抹1 mL透明质酸钠凝胶)、t-BHQ1组和t-BHQ2组(行腹腔粘连造模,术后分别予以25、50...
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| 关 键 词： | 术后腹腔粘连 Nrf2 t-BHQ 氧化应激反应 |
Value of Nrf2 agonist t-BHQ in the prevention of postoperative abdominal adhesion formation and its possible mechanism |
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| WU Yunhua,YANG Ni,WANG Xingjie,WU Yutong,WANG Zijun,WANG Shufeng,LI Xuqi,WEI Guangbing. Value of Nrf2 agonist t-BHQ in the prevention of postoperative abdominal adhesion formation and its possible mechanism[J]. Clinical Research and Practice, 2021, 6(13): 1-3,15 |
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| Authors: | WU Yunhua YANG Ni WANG Xingjie WU Yutong WANG Zijun WANG Shufeng LI Xuqi WEI Guangbing |
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| Affiliation: | (No.2 General Surgery Department,Shaanxi Provincial People's Hospital,Xi'an 710068;General Surgery Department,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China) |
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| Abstract: | Objective To explore the value of Nrf2 agonist t-BHQ in preventing postoperative abdominal adhesion formation and its possible mechanism.Methods Forty SD rats were randomly divided into Sham group(only open and close abdominal operation),Control group(abdominal adhesion model),HA group(abdominal adhesion model,1 mL sodium hyaluronate gel was evenly applied at the adhesion site before abdominal closure),t-BHQ1 group and t-BHQ2 group(abdominal adhesion model,25,50 mg/kg t-BHQ were given by gavage after operation).The severity of adhesion formation of each groups was evaluated by Nair's score.HE staining and Nrf2 immunohistochemical staining were performed on the postoperative abdominal adhesion tissues,and the expression levels of MDA and SOD in the tissues were detected.Results Compared with the Control group,the Nair's score and inflammation score of HE staining in the t-BHQ1 group and t-BHQ2 group decreased,the Nrf2 immunohistochemical score increased,and the expression level of SOD in the adhesive tissue increased,while the expression level of MDA decreased(P<0.05).Conclusion Nrf2 agonist t-BHQ can inhibit the formation of postoperative abdominal adhesions by reducing inflammation and oxidative stress response. |
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| Keywords: | postoperative abdominal adhesion Nrf2 t-BHQ oxidative stress response |
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