Antioxidant and antipyretic properties of methanolic extract of Amaranthus spinosus leaves |
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| Authors: | Bagepalli Srinivas Ashok Kumar Kuruba Lakshman KN Jayaveera Devangam Sheshadri Shekar Avalakondarayappa Arun Kumar Bachappa Manoj |
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| Institution: | 1. Department of Pharmacognosy, Sri K.V. College of Pharmacy, Chickballapur, Karnataka, India;2. Department of Pharmacognosy, PES College of Pharmacy, Bangalore, Karnataka, India;3. Department of Chemistry, Jawaharlal Nehru Technological University of College of Engineering, Anantapur, Andhra Pradesh, India;4. Department of Pharmacology, Sri K.V. College of Pharmacy, Chickballapur, Karnataka, India |
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| Abstract: | ObjectiveMethanolic extract of Amaranthus spinosus (A. spinosus) leaves was screened for antioxidant and antipyretic activities.MethodsAntioxidant activity was measured by 1,1-diphenyl-2-picryl-hydrazile (DPPH) free radical scavenging, superoxide anion radical scavenging, hydroxyl free radical scavenging, nitric oxide radical scavenging, 2,2 '-azinobis-3-ethylbenzothiazole-6-sulfonic acid (ABTS) radical scavenging assays and total phenolic content was also determined. Antipyretic activity of methanolic extract of A. spinosus was measured by yeast induced pyrexia method at concentration of 200 and 400 mg/kg using paracetamol as standard drug.ResultsMethanolic extract of A. spinosus showed potent antioxidant activity. The IC 50 value was (87.50 ±3.52) μg/mL, (98.80±1.40) μg/mL, (106.25±0.20) μg/mL, (88.70±0.62) μg/mL and (147.50±2.61) μg/mL for DPPH, superoxide, hydroxyl, nitric oxide and ABTS radical scavenging activities. Methanolic extract of A. spinosus showed significant (P <0.01) antipyretic activity. |
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