Polymorphisms of MMP-2 Gene are Associated With Systolic Heart Failure Risk in Han Chinese |
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Authors: | Yihong Hua Naqiong Wu Yuejin Yang Xiangfeng Lu Xianmin Meng Li Song Dongfeng Gu |
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Institution: | 1. National Key Discipline of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, China;2. The First Affiliated Hospital, Harbin Medical University, China;3. Institute for Nutrisciences and Health, National Research Council Canada, Charlottetown, PE, Canada;4. State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China;1. Cardiology Department-Fundación Asturcor, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain;2. Genetics Department, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain;3. Bone and Mineral Research Unit, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain;4. REDinREN from Instituto de Salud Carlos III, Spain |
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Abstract: | BackgroundMatrix metalloproteinases (MMPs) are a family of proteolytic enzymes responsible for protein degradation. MMP-2 has been demonstrated to play a pivotal role in myocardial remodeling process that occurs in congestive heart failure (HF). We hypothesized that MMP-2 genetic variations could be associated with systolic HF risk.MethodsTo test the association of single nucleotide polymorphisms of MMP-2 with systolic HF risk, we performed a hospital-based, case-control study of 605 patients with systolic HF and 689 controls without HF. Three single nucleotide polymorphisms of MMP-2 (rs243864, rs243866, and rs17859821) were genotyped by restriction fragment length polymorphism methods.ResultsThe genotype frequencies of MMP-2 rs243866 AA and AG in the control group were significantly higher than that in the case group (24.7% versus 17.9%, P < 0.01). Compared with the GG homozygotes, MMP-2 rs243866 A allele carriers had a significantly lower risk of systolic HF (adjusted OR 0.69, 95% CI 0.49-0.98; P = 0.035). Haplotype analysis indicated the haplotype GGG (rs243864-rs17859821-rs243866) was associated with higher risk of systolic HF (adjusted OR 2.05, 95% CI 1.08-3.89; P = 0.028).ConclusionThe findings of the current study suggest that MMP-2 rs243866 A allele was associated with lower risk of systolic HF in Han Chinese. |
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