正己烷接触员工相关指标研究

目的正己烷接触员工相关指标研究。方法选取生产工艺和生产用油墨基本相同的3个（A、B、C）印刷车间，检测3个车间现场正己烷浓度，每个车间随机抽取40名员工，测定其神经传导速度（NCV）和红细胞膜收缩蛋白（Sp）的共价交联异常情况，并观察三者的关系。选择40名办公室员工作作对照。结果C车间部分员工正中神经传导速度减慢，当正己烷浓度〉44．7mg／m^3时，吸光度扫描的共价交联sp差异有统计学意义（分别与办公室员工、A车间员工比较，P〈0．05）。结论高浓度正己烷可致神经源性损害，共价交联Sp作为正己烷神经毒性的替代生物标志物有一定研究价值。

Study of N-hexane Exposure-related Indexes in Employees

Objective]To study the N-hexane exposure-related indexes in employees. Methods]Three different workshops (A, B, C) with similar processing technique and production ink were selected. The concentration of onsite n-hexane was measured, 40 employees from each workshop were randomly selected to detect covalent cross-linking abnormalities of nerve conduction velocity (NCV) and Erythrocyte Spectrin, and the relationships between them were observed. 40 office workers were selected for the control.Results]The median nerve conduction velocity of some employees in workshop C decreased, when the concentration of n-hexane was more than 44.7mg/m3, the difference of covalent cross-linking Sp was significant by absorbance scanning (compared with office workers and workers in A workshop respectively, P<0.05).Conclusion]Neurogenic damage can be caused by high concentrations of n-hexane. Covalent cross-linking Sp as the surrogate biomarker to n-hexane neurotoxicity has a certain research value.