| 蛛网膜下腔出血与内皮素和降钙基因相关肽的关系研究 |
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| 引用本文： | 张泽兰,谭华,陈秀,甘西伦.蛛网膜下腔出血与内皮素和降钙基因相关肽的关系研究[J].中国现代医学杂志,2000,10(12):10-11. |
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| 作者姓名： | 张泽兰 谭华 陈秀 甘西伦 |
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| 作者单位： | 1. 四川泸州医学院附属医院神经内科,646000
2. 四川泸州医学院附属医院核医学科 |
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| 摘 要： | 目的：探讨蛛网膜下腔出血（ＳＡＨ）后血液、脑脊液中内皮素（ＥＴ）、降钙基因相关肽（ＣＧＲＰ）含量变化及与血管痉挛（ＣＶＳ）的关系。方法：用放免法检测３２例不同时期、不同病因、不同病情ＳＡＨ患者血液、ＣＳＦ中ＥＴ、ＣＧＲＰ含量变化并与对照组比较。结果：ＳＡＨ后血浆、ＣＳＦ中ＥＴ对照组明显升高，Ｐ〈０．０５。ＣＧＲＰ则明显低于对照组，Ｐ〈０．０１。ＥＴ升高和ＣＧＲＰ降低与病情程度、病后时间有关，与引起ＳＡＨ的原因无关。结论：ＥＴ和ＣＧＲＰ的变化与ＳＡＨ后脑血管痉挛有关，可作为ＳＡＨ后血管痉挛（ＣＶＳ）的一种观察指标。
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| 关 键 词： | SAH 内皮素 降钙基因相关肽 血管痉挛 |
| 修稿时间： | 2000年7月13日 |
SUBARACHNOID HEMORRHAGE AND ET AND CGRP |
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| Zhang Zelan,Tan Hua,Chen Xiu,et al..SUBARACHNOID HEMORRHAGE AND ET AND CGRP[J].China Journal of Modern Medicine,2000,10(12):10-11. |
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| Authors: | Zhang Zelan Tan Hua Chen Xiu |
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| Institution: | Zhang Zelan,Tan Hua,Chen Xiu,et al. Department of Neurology,Affiliated Hospital to Luzhou Medical College,Luzhou 646000 |
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| Abstract: | Objective:To discuss the relationship between cerebral vasospasm (CVS)and content changes of endothelin(ET)and CGRP in plasma and CSF after subarachnoid hemorrhage (SAH).Methods: To detect the content changes of ET and CGPR in plasma and CSF of 32 SAH patients of different period, different pathogeny and different state with radioimmunity and compare with normal control group.Results:ET in plasma and CSF after SAH was much higher than that of normal control group, P< 0.05.CGRP was significantly lower than that of normal controls group. P< 0.01.Elevotory of ET and reduce of CGRP were related to the state of illness and time after sickness,and were foreign to the reason that caused SAH.Conclusions:The changes of ET and CGRP are related to cerebral vasospasm after SAH.ET and CGRP are regarded as an observtive indication of CVS after SAH. |
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| Keywords: | SAH ET CGRP X |
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