| 下丘脑内基因转染对大鼠颞叶癫痫海马病理变化的影响 |
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| 引用本文： | 孟红梅,林卫红,王赞,张淑琴,佐治真理.下丘脑内基因转染对大鼠颞叶癫痫海马病理变化的影响[J].中风与神经疾病杂志,2003,20(6):490-491. |
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| 作者姓名： | 孟红梅 林卫红 王赞 张淑琴 佐治真理 |
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| 作者单位： | 1. 吉林大学第一医院神经内科,吉林,长春,130021
2. 北里大学脑机能研究所,日本,神奈川县,2288555 |
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| 摘 要： | 目的 探讨下丘脑过度兴奋对于颞叶癫痫海马病理变化的影响。方法 利用仙台病毒(HVJ)-脂质体转染法在下丘脑的乳头体内转染兴奋性氨基酸受体亚基GluR2Q，研究其对于海人酸(kainic acid，KA)致痫鼠海马病理变化的影响。结果 GluR2Q能加重KA引起的海马齿状回损伤，但是对CA1及CA3区神经元损伤有一定程度的改善作用。结论 GluR2Q可以使下丘脑兴奋性增强，通过对海马齿状回的抑制解除作用促进癫痫波在海马内的传播。
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| 关 键 词： | 下丘脑 基因转染 大鼠 颞叶癫痫 海马 病理变化 |
| 文章编号： | 1003-2754(2003)06-0490-02 |
| 修稿时间： | 2003年5月18日 |
Gene transfer in the hypothalamus contributes to the hippocampus injury of limbic seizures |
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| MENG Hong-mei,LIN Wei-hong,WANG Zan,et al..Gene transfer in the hypothalamus contributes to the hippocampus injury of limbic seizures[J].Journal of Apoplexy and Nervous Diseases,2003,20(6):490-491. |
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| Authors: | MENG Hong-mei LIN Wei-hong WANG Zan |
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| Abstract: | Objective To investigate the hippocampus injury o f limbic seizures by overexciting of hipothalamus.Methods GluR2Q gene was transfered in the Supramammillary(SuM) of hypothalamus by HVJ-liposome . Hippocampus injury of limbic seizures with or without intra-SuM delivery of G luR2Q cDNA was observed.Results Severe damage of dentate gyrus( DG) granule cells and the rescue of CA 3 and CA 1 neurons were observed in Glu R2Q-expressing rats.Conclusion Overexpression of GluR2Q in the hypothalamus area may cause the activation of the stimulative hypothalamic affe rents and the disinhibition mechanism to DG,which results in the intensification of epileptogenesis in the hippocampus. |
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| Keywords: | Liposome Glutamate receptor Limbic seizure Hippocampus |
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