| 小剂量阿奇霉素长期使用治疗慢性呼吸道感染疾病的安全性探讨 |
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| 引用本文： | 金玲湘,颜雪琴,翁海霞.小剂量阿奇霉素长期使用治疗慢性呼吸道感染疾病的安全性探讨[J].中国临床药理学与治疗学,2003,8(2):213-214. |
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| 作者姓名： | 金玲湘 颜雪琴 翁海霞 |
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| 作者单位： | 温州医学院附属二院呼吸内科,温州,325027,浙江 |
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| 摘 要： | 目的：探讨小剂量阿奇霉素长期使用的安全性。方法：观察了76例慢性呼吸道感染病人口阿奇霉素0.25g，每日1次，62例慢性呼吸道感染病口服阿莫西林0．5g，每日3次，疗程6wk。结果：长期口服小剂量阿奇霉素，副作用的发生率为10．5％，与阿莫西林相比无显的统计学意义（P＞0．05），但阿莫西林组皮疹发生率高（P＜0．05）。结论：长期口服小剂量阿奇霉素治疗慢性呼吸道感染疾病是安全的。
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| 关 键 词： | 药效学 阿奇霉素 副作用 慢性呼吸道感染 |
| 文章编号： | 1009-2501(2003)02-0213-02 |
| 修稿时间： | 2002年10月29 |
Clinical safety of long-term and low-dose usage of azithromycin in treatment of patients with chronic respiratory tract infection |
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| JIN Ling Xing,YAN Xue Qing,WEN Hai Xia.Clinical safety of long-term and low-dose usage of azithromycin in treatment of patients with chronic respiratory tract infection[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2003,8(2):213-214. |
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| Authors: | JIN Ling Xing YAN Xue Qing WEN Hai Xia |
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| Institution: | JIN Ling Xing,YAN Xue Qing,WEN Hai Xia Department of Respiration,the Second Affiliated Hospital,Wenzhou Medical College,Wenzhou 325027,Zhejiang |
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| Abstract: | AIM: To observe the clinical safety of azithromycin with low dose and long term usage. METHODS: The safety profile was assessed in 76 patients with chronic respiratory tract infective diseases received 0.25 g azithromycin once a day over 6 weeks orally; and 62 patients by 0.5 g amoxicillin three times a day over 6 weeks orally. RESULTS: The rate of side effects was 10.5 % with azithromycin, similar to that with amoxicillin (P> 0.05 ); but rate of skin rash was increased in the patients with amoxicillin (P< 0.05 ). CONCLUSION: The long term usage of azithromycin with low dose was safety in treatment of patients with chronic respiratory tract infective diseases. |
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| Keywords: | pharmacodynamics azithromycin side effects chronic respiratory tract infection |
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