莫沙必利和四磨汤治疗慢性功能性便秘的临床观察

目的　观察莫沙必利和四磨汤治疗慢性功能性便秘的临床疗效。方法　将 78例患者随机分为莫沙必利组、四磨汤组和两药联用组 3组 ,观察治疗前后症状的变化。结果　治疗的总有效率分别为 :莫沙必利组 6 1 .5 % ,四磨汤组 6 9.2 % ,两组差异无显著意义 (P>0 .0 5 ) ;两药联用组 92 .3% ,高于单独使用莫沙必利组 (P<0 .0 1 )和四磨汤组 (P<0 .0 5 )。四磨汤组在改善便秘伴随的腹胀和腹痛上优于莫沙必利组 (P<0 .0 5 )。结论　莫沙必利和四磨汤均是治疗慢性功能性便秘的有效药物且疗效相近 ,两药联合应用可提高治疗效果

Clinical observation effect of mosapride and simo decoction on chronic functional constipation

Objective To observe the clinical effect of mosapride and simo decoction on chronic functional constipation.Methods Seventy eight cases of chronic functional constipation were divided into such three groups as mosapride group,simo decoction group,and mosapride combined with simo decoction group.The clinical symptoms of chronic functional constipation were recorded before and after treatment.Results The total effective rates were 61.5 %,69.2% and 92.3% in mosapride group,simo decoction group and mosapride combined with simo decoction group.The total effective rates in mosapride group were similar to those in simo decoction group( P >0.05).The total effective rates in mosapride combined with simo decoction group were significantly higher than that in mosapride group( P <0.01) and in simo decoction group( P <0.05).Simo decoction group was more effective than mosapride group in improving symptoms of abdominal distension and abdominalgia( P <0.05).Conclusion Mosapride combined with simo decoction is more effective in improving symptoms of chronic functional constipation.