胱抑素C和超敏C反应蛋白联合检测在糖尿病早期肾损害诊断中的价值

目的探讨2型糖尿病（T2DM）患者血清中胱抑素c（Cysc）和超敏c反应蛋白（hs—CRP）的水平测定对诊断糖尿病早期肾损害价值。方法180例T2DM患者根据尿肾功能指标（包括尿微量清蛋白（mAlb）、尿β2-微球蛋白（β2-MG）、N-乙酰-β-D氨基葡萄糖苷酶（NAG））分为尿肾功正常组和尿肾功异常组各90例，100例健康者为对照组。采用Olympus Au640全自动生化分析仪分别检测血清中的Cysc以及hs—CRP水平，并对检测结果进行统计学分析。结果T2DM患者Cysc以及hs—CRP水平均高于对照组（P〈0．01），尿肾功异常组患者的Cysc以及hs—CRP水平也明显高于尿肾功正常组（P〈0．01），在T2DM患者中，血清中的Cysc与hs—CRP呈正相关（r=0．39）。结论Cyse、hs—CRP作为诊断糖尿病早期肾损害的敏感指标，联合检测更具实用价值。

Diagnostic value of the combinative measuring of serum cystatin C and high sensitivity C-reactive protein in diabetic mellitus patients with early renal injury

Objective To explore the clinical diagnostic value of the combinative measuring of serum cystatin C and high sensitivity C-reactive protein in type 2 diabetic mellitus （T2DM） patients with early renal injury. Methods According to urine renal function indice （including urinary microalbumin, urinaryβ2-microglobumin and N-aletyl-β-D-glucosaminidase）, 180 patients with T2DM were divided into two groups： urine renal function normal group （n= 90） and urine renal function abnormal group （n=90）. 100 healthy people were served as control group. The levels of serum Cys C and hs-CRP were examined with Olympus AU640 automatic biochemical analyzer and statistical analysis was carried out. Results The levels of serum Cys C and hs-CRP in patients with T2DM were significantly higher than those in control group （P〈0.01） ; while the levels of serum Cys C and hs-CRP in urine renal function abnormal group were significantly increased than those in urine renal function normal group （P〈0.01）. Serum Cys C was positively correlated with hs-CRP（r=0.39）in T2DM patients. Conclusion Cys C and hs-CRP may be used as sensitive indite of diagnosing early renal injury in type 2 diabetic mellitus. Combinative measuring had more practical value.