糖尿病模型红细胞变形能力及酶活性变化

目的 复制糖尿病模型并观察糖尿病（ＤＭ）红细胞变形能力（ＲＣＤ）及酶活性变化。并探讨了ＤＭ早期上述指标改变与慢性并发症的关系。方法 用四氧嘧啶制备家兔糖尿病模型，测定ＲＣＤ和红细胞膜ＡＴＰ酶活性，膜唾液酸（ＳＡ）含量及红细胞中超氧化物歧化酶（ＳＯＤ）活性和丙二醛（ＭＤＡ）含量。结果 糖尿病模型ＲＣＤ和红细胞膜，ＡＴＰ酶活性，ＳＡ含量和细胞内ＳＯＤ含量及ＭＤＡ均降低，结论 糖尿病早期即有红细胞形态和

The deformability chage of red cells and enzyme active in diabetic rabbits model

Objective A rabbit model of deabetes mellitus was reproduced and observe the deformabiolty change ofred cells and enzyme active in diabetic rabbits and discuss the relations between the above observation and chronicdiseases in early phase of diabetes.Methods A rabbit model of diabetes mellitus was reproduced by injectionalloxan The change of RCD the activity of Ma -K -ATPase,Ca -Wg -ATPase and tha content ofmalondialdehydein erythrocyte membrane,the activity of superoxide dismutase and the content of sialic acid (SA)in erythocyte were observed.Results The decrease of RCD in diabetic rabbits under experiment was related tothe change of the activity of Ma -K -TPase,Ca2 -Mg -ATP ase and the content of SA in erythrocytemembrane, and SOD in erythrocyte and the change of MDA levle.Conclusions There is a change of theerythrocyte membrane shape and enzyme active of diabetes,and this change will led to the chronic dieases in earlyphase of diabetes.