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Targeting MYC-driven replication stress in medulloblastoma with AZD1775 and gemcitabine |
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| Authors: | Moreira Daniel C. Venkataraman Sujatha Subramanian Apurva Desisto John Balakrishnan Ilango Prince Eric Pierce Angela Griesinger Andrea Green Adam Eberhardt Charles G. Foreman Nicholas K. Vibhakar Rajeev |
| Affiliation: | 1.Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA ;2.Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children’s Hospital Colorado, Aurora, CO, USA ;3.Department of Neurosurgery, University of Colorado Denver, Aurora, CO, USA ;4.Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA ;5.Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN, USA ; |
| Abstract: | Journal of Neuro-Oncology - MYC-driven medulloblastomas are highly aggressive childhood tumors with dismal outcomes and a lack of new treatment paradigms. We identified that targeting replication... |
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