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Repolarization of tumor infiltrating macrophages and increased survival in mouse primary CNS lymphomas after XPO1 and BTK inhibition |
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| Authors: | Jiménez Isabel Carabia Júlia Bobillo Sabela Palacio Carles Abrisqueta Pau Pagès Carlota Nieto Juan C. Castellví Josep Martínez-Ricarte Francisco Escoda Lourdes Perla Cristóbal Céspedes Torrez Dennis H. Boix Joan Purroy Noelia Puigdefàbregas Lluís Seoane Joan Bosch Francesc Crespo Marta |
| Affiliation: | 1.Experimental Hematology, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron Barcelona Hospital Campus, C/Natzaret, 115-117, Barcelona, 08035, Spain ;2.Department of Medicine, Universitat Autònoma de Barcelona, Bellaterra, 08193, Spain ;3.Department of Hematology, Experimental Hematology, Vall d’Hebron Hospital Universitari, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron Barcelona Hospital Campus, Passeig Vall d’Hebron 119-129, Barcelona, 08035, Spain ;4.Department of Pathology, Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Passeig Vall d’Hebron 119-129, Barcelona, 08035, Spain ;5.Department of Neurosurgery, Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Passeig Vall d’Hebron 119-129, Barcelona, 08035, Spain ;6.Department of Hematology, Hospital Universitari Joan XXIII, Tarragona, Spain ;7.Department of Neurosurgery, Hospital Universitari Joan XXIII, Tarragona, Spain ;8.Translational Research Program, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron Barcelona Hospital Campus, C/Natzaret, 115-117, 08035, Barcelona, Spain ;9.Institució Catalana de Recerca I Estudis Avan?ats (ICREA), CIBERONC, Barcelona, Spain ;10.Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts and Broad Institute of MIT and Harvard, Cambridge, MA, UK ; |
| Abstract: | Journal of Neuro-Oncology - Patients diagnosed with primary central nervous system lymphoma (PCNSL) often face dismal outcomes due to the limited availability of therapeutic options. PCNSL cells... |
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