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西沙必利治疗非溃疡性消化不良
引用本文:郭文有,齐秀恒.西沙必利治疗非溃疡性消化不良[J].中国新药与临床杂志,1996(1).
作者姓名:郭文有  齐秀恒
作者单位:中国石油天然气总公司管道局医院
摘    要:目的:验证西沙必利(cisapride)对非溃疡性消化不良的疗效。方法:采用双盲随机将86例非溃疡性消化不良病人分为2组。西沙必利组46例(男性33例,女性13例;年龄36±s8a),用西沙必利5mg,po,tid;安慰剂组40例(男性29例,女性11例;年龄34±10a),用安慰剂1片,po,tid,2组均4wk为一个疗程。治疗后1~4wk通过直接提问来评价2组病人症状改善情况。结果:西沙必利对非溃疡性消化不良的症状改善率和症状严重程度的改善皆较安慰剂组有明显的效果(P<0.01)。结论:西沙必利对治疗非溃疡性消化不良有效。

关 键 词:西沙必利  双盲法  消化不良

Cisapride in treating non-ulcer dyspepsia
GUO Wen-You, QI Xiu-Heng.Cisapride in treating non-ulcer dyspepsia[J].Chinese Journal of New Drugs and Clinical Remedies,1996(1).
Authors:GUO Wen-You  QI Xiu-Heng
Abstract:AIM : To observe the effect of cisapride on non- ulcer dyspepsia. METHODS : Eighty- six patients with non- ulcer dyspepsia were randomly assigned to 2 groups : 46 patients ( M 33,F 13; age 36 ± s 8 a) were treated with cisapride 5 mg po tid and 40 patients (M29. F 11 ; age 34 ± 10 a ) received placebo 1 tablet,po tid. Both groups were treated for 3 wk. RESULTS; The rate of symptom improvement in cisapride group was superior to that of the placebo group. P< 0. 01. Cisapride had no marked side reaction. CONCLUSION : Cisapride is a safe and effective drug for treatment of non- ulcer dyspepsia.
Keywords:cisapride  double- blind method  dyspepsia  
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