21例宫颈癌术前新辅助化疗的疗效观察

目的探讨术前新辅助化疗（NACT）对巨块型宫颈癌的疗效。方法选择2004年1月至2008年12月经病理确诊的21例ⅠB2～ⅡB期巨块型宫颈癌,采用顺铂、长春花碱、博菜霉素联合方案（PVB）化疗2个疗程后手术。结果化疗后临床有效率达85.7%,肿瘤直径较化疗前有不同程度的缩小,差异有统计学意义（P＜0.01）,所有患者均能顺利切除病灶。结论术前新辅助化疗可提高手术切除率和症状改善率,提高宫颈癌的疗效,为治疗该病的一种有效手段,具有重要的临床意义。

Observation on the curative effect of pre-operation neoadjuvant chemotherapy for the patients with cervical cancer

Objective To investigate the effect of preoperative neoadjuvant chemotherapy on the patients with Ⅰ B2- Ⅱ B bulky cervical cancer. Methods Totally 21 cases of bulky cervical cancer in stage Ⅰ B2- ⅡB were diagnosed by pathology in our hospital from 2004 to 2008. They were trented by regimen of PVB chemotherapy for 2 cycles and followed by operation. Results The rate of overall response was 85.7%. The primary tumor sizes were significantly decreased after chemotherapy, compared with the condition before （P〈0.01）. All the patients underwent radical hysterectomy could recover easily. Conclusion Preoperative neoadjuvant chemotherapy could apparently increase the chance of success in operation and perfect the remission rate. So it is an effective method for treatment of stage ⅠB2-ⅡB bulky cervical cancer,and it shows promising prospect in clinical application.