齐拉西酮与氟哌啶醇治疗精神分裂症对照研究

目的：探讨齐拉西酮治疗精神分裂症的疗效及不良反应。方法：将符合入组标准的100例精神分裂症患者随机分为齐拉西酮组与氟哌啶醇组各50例。进行为期8周的治疗。采用阳性与阴性症状量表（PANSS）评定疗效、副反应量表CRESS）评定副反应。结果：氟哌啶醇组有效率为74％，显效率为38％；齐拉西酮组有效率为84％，显效率为72％。两组药物显效率比较，差异有统计学意义（P〈0．01）；阳性与阴性症状量表评分，两组治疗第4周末起总分及各因子分与治疗前比较，差异有统计学意义（P均〈0．01）。结论：该两种药物对精神分裂症均有确切疗效，且安全性相对较高，齐拉西酮对症状的改善效果更好，不良反应轻微。

A comparative study of ziprasidone and haloperidol in the treatment for schizophrenia

Objective： To explore the effect and adverse reactions of ziprasidone in the treatmet of schizophrenia. nethods：100 cases of schizophrenia conforming to standard were randomly divided into ziprasidone group and haloperidol group for eight weeks. The efficiency and adverse reactions were assessed with positive and negative syndrome scale （PANSS） and treatment emergent symptom scale（TESS） respectively. Results： There were no significant differeces between haloperidol group and ziprasidone group in improved （74% vs 84%） and markedly response rate （38% vs 72%）. The efficiency of the two groups had significantly differences（P〈0.01）. Had given four weeks medical care to both groups of the positive and negative syndrome scale（PANSS）, The author got a total score and the factor scores in a very significant difference from those before treatment（P〈0.01）. Conclusion： The two drugs have an accurate effect on schizophrenia,and the security is relatively high,while ziprasidone is a bit better in symptom improvement and its adverse reactions are mild.