| 乙型肝炎患者CD4~+CD25~+调节性T细胞水平与HBV病毒载量相关性 |
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| 引用本文： | 王玉辉.乙型肝炎患者CD4~+CD25~+调节性T细胞水平与HBV病毒载量相关性[J].中国热带医学,2010,10(1):15-16. |
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| 作者姓名： | 王玉辉 |
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| 作者单位： | 北华大学附属医院检验科,吉林,吉林,132011 |
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| 摘 要： | 目的了解乙型肝炎患者外周血Tregs水平并探讨其在乙型肝炎病人发病机制中的作用。方法采用流式细胞术检测乙型肝炎患者及对照组外周血Tregs的水平及应用PCR技术测定其HBVDNA载量。结果1.CSHB组Tregs的百分率较CHB组有明显差异(P0.05),比无症状携带者组及健康对照组则有显著差异(P均0.01);2.AHB组较健康对照组的稍低,但无统计学意义(P0.05),且明显低于CHB组(P0.01);3.CHB组与无症状携带者组及健康对照组相比,具有明显的差异(P0.05);无症状携带者组与健康对照组相比无显著差异(P0.05)。4.CSHB组外周血HBVDNA载量较其他三组明显偏低(P均0.01);CHB组与无症状携带者组、AHB组相比,差异性不大(P均0.05);无症状携带者组与AHB组相比,差异性不大(P均0.05)。5.不同乙型肝炎病人外周血Tregs的百分率与HBVDNA载量正相关。结论1.Tregs的水平与乙肝患者病情轻重有一定关系,它在HBV的持续感染中可能发挥了重要作用。2.不同乙型肝炎患者外周血Tregs的百分率与HBVDNA载量呈正相关。
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| 关 键 词： | Tregs 乙型肝炎 |
Correlation of levels of CD4+CD25+Tregs with HBV load in hepatitis B patients |
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| WANG Yu-hui.Correlation of levels of CD4+CD25+Tregs with HBV load in hepatitis B patients[J].China Tropical Medicine,2010,10(1):15-16. |
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| Authors: | WANG Yu-hui |
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| Institution: | WANG Yu-hui. (Laboratory Department of Affifiated Hospital of Beihua University, Jilin 132011, Jilin, P. R.China) |
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| Abstract: | Objective To investigate the level of Tregs in peripheral blood of hepatitis B patients and explore the possible role of Tregs in the pathogenesis of hepatitis B patients. Methods The frequency of Tregs in PBMCs from hepatitis B patients were detected by flow cytometry and their HBV DNA serum levels were detected by PCR. Results A higher proportion of Tregs in PBMCs was observed in CSHB patients compared with CHB patients (P <0.05),chronic asymptomatic HBV carriers( P<0.01)and healthy controls(P<0.01).and a... |
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| Keywords: | Tregs Hepatitis B |
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