Role of shear stress and immune responses in liver regeneration after a partial hepatectomy |
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Authors: | Yoshinobu Sato Kazuhiro Tsukada Katsuyoshi Hatakeyama |
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Institution: | (1) First Department of Surgery, Niigata University School of Medicine, 1-754 Asahimachi-dori, 951 Niigata, Japan |
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Abstract: | This report reviews studies addressing the new concepts in liver regeneration after a partial hepatectomy (PHx). The review
begins with an overview of the immunologic mechanisms of liver regeneration after PHx, especially regarding Kupffer cells
and extrathymic T cells of the regenerative liver in the cell-mediated immunity, based on major histocompatibility complex
I and II antigens. Attention is then devoted to “on and off” studies in liver regeneration after PHx, by hypothesizing the
shear stress based on the fact that the portal flow against hepatocytes or sinusoidal endothelial cells triggers their regeneration
after a partial hepatectomy and controls the volume of the regenerating liver by the stimulating the cell surface modulator
(CSM) of hepatocytes and sinusoidal endothelial cells (SEC). We propose that the acute elevation of shear stress after PHx
influences the adhesion between SEC and intrahepatic leukocytes. These concepts are expected to positively contribute to the
future research on liver regeneration after PHx. |
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Keywords: | Liver regeneration shear stress immunity major histocompatibility complex sieve plates space of Disse |
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