| 液质联用技术检测硫酸多黏菌素B中各组分 |
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| 引用本文： | 刘孟娟,周陈西,胡方剑.液质联用技术检测硫酸多黏菌素B中各组分[J].中国药业,2011,20(19):32-33. |
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| 作者姓名： | 刘孟娟 周陈西 胡方剑 |
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| 作者单位： | 1. 浙江省肿瘤医院药剂科,浙江,杭州,310022
2. 杭州中美华东制药有限公司,浙江,杭州,310022 |
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| 摘 要： | 目的建立硫酸多黏菌素B的液质联用分析方法,确定多黏菌素B中各组分。方法按照第6版《欧洲药典》液相色谱法分离多黏菌素B各组分,采用液质联用技术测定各个组分相对分子质量进行验证。结果多黏菌素B实际样品中存在4个组分,分别为多黏菌素B1,B2,B3,B1-I。其主要组分为多黏菌素B1。结论液质联用技术用于多粘菌素的质量控制,方法准确、可行。
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| 关 键 词： | 多黏菌素B 组分 液质联用 |
LC-MS Research on the Components of Polymyxin B |
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| Liu Mengjuan,Zhou Chenxi,Hu Fangjian.LC-MS Research on the Components of Polymyxin B[J].China Pharmaceuticals,2011,20(19):32-33. |
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| Authors: | Liu Mengjuan Zhou Chenxi Hu Fangjian |
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| Institution: | Liu Mengjuan1,Zhou Chenxi1,Hu Fangjian2(1.Department of Pharmacy,Zhejiang Cancer Hospital,Hangzhou,Zhejiang,China 310022,2.Hangzhou Zhongmei Huadong Pharmaceuticals Co.,Ltd.,China 310022) |
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| Abstract: | Objective To establish the analytical method of LC-MS technology of polymyxin B,in order to determine the relative components in polymyxin B.Methods The relative components in polymyxin B were separated according to the liquid phase method recorded in European Pharmacopoeia（EP 6.0）.LC-MS technology was used to identify the molecular weight of singulorum components.Results Four components of polymyxin B were determined after LC-MS analysis,there were polymyxin B1,B2,B3 and B1-Ⅰ,of which the polymyxin B1 was the most component.Conclusion LC-MS technology might be a new method for quality control of polymyxin B. |
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| Keywords: | polymyxin B component LC-MS |
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