| 高效液相色谱法测定通脉颗粒中阿魏酸含量 |
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| 引用本文： | 李军山,白新涛,张博.高效液相色谱法测定通脉颗粒中阿魏酸含量[J].中国药业,2011,20(17):37-38. |
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| 作者姓名： | 李军山 白新涛 张博 |
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| 作者单位： | 神威药业有限公司,河北,石家庄051430 |
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| 摘 要： | 目的建立测定通脉颗粒中阿魏酸含量的高效液相色谱法。方法色谱柱为Dionex C18柱(250 mm×4.6 mm,5μm),流动相为甲醇-1%醋酸溶液(30∶70),流速为1.0 mL/min,测定波长为321 nm。结果平均回收率为98.72%,RSD为0.73%,阿魏酸质量浓度在0.507～15.210μg/mL范围内与峰面积线性关系良好,系统精密度的RSD为0.01%。结论高效液相色谱法测定通脉颗粒中阿魏酸含量,可用于通脉颗粒的质量控制。
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| 关 键 词： | 高效液相色谱法 通脉颗粒 阿魏酸 含量测定 |
Content Determination Ferulic Acid in Tongmai Granules by HPLC |
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| Li Junshan,Bai Xintao,Zhang Bo.Content Determination Ferulic Acid in Tongmai Granules by HPLC[J].China Pharmaceuticals,2011,20(17):37-38. |
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| Authors: | Li Junshan Bai Xintao Zhang Bo |
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| Institution: | Li Junshan,Bai Xintao,Zhang Bo(Shineway Pharmaceutical Co.,Ltd.,Shijiazhuang,Hebei,China 051430) |
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| Abstract: | Objective To establish HPLC method for determination of ferulic acid in Tongmai Granules.Methods Chromatographic column is Dionex C18 column（250 mm×4.6 mm,5 μm）;the mobile phase is methanol-1%acetic acid solution（30：70）;and the flow rate is 1.0 mL/min;the wavelength is 321 nm.Results The average recovery rate is 98.72%,the relative standard difference（RSD） is 0.73%,the linear range of ferulic acid is 0.507-15.210 μg/mL,and the system precision is 0.01%.Conclusion It is available to control the quality of Tongmai Granules by applying HPLC to determine the content of ferulic acid. |
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| Keywords: | HPLC Tongmai Granules ferulic acid content determination |
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