| 纳洛酮对大鼠肾脏缺血-再灌注损伤的保护作用 |
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| 引用本文： | 黄黎芳.纳洛酮对大鼠肾脏缺血-再灌注损伤的保护作用[J].中国药业,2011,20(19):11-12. |
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| 作者姓名： | 黄黎芳 |
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| 作者单位： | 四川省自贡市第四人民医院药剂科,四川,自贡,643000 |
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| 摘 要： | 目的 研究纳洛酮对大鼠肾脏缺血-再灌注损伤的保护作用.方法 利用大鼠肾脏缺血-再灌注损伤模型,观察纳洛酮对肾脏缺血-再灌注后血液中丙二醛(MDA)、超氧化物歧化酶(SOD)及肾组织中Na+-K+-ATP,Ca2+-ATP酶的影响,并观察组织病理学变化.结果 肾脏缺血-再灌注后,MDA含量明显升高,SOD活力明显降低;肾组织Na+-K+-ATP酶和Ca2+-ATP酶活力均显著降低.肌肉注射纳洛酮后,MDA显著下降,SOD和Na+-K+-ATP酶、Ca2+-ATP酶活力均明显升高,肾小管上皮细胞的损伤明显减轻.结论 纳洛酮对肾脏缺血-再灌注损伤有一定的保护作用.
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| 关 键 词： | 纳洛酮 缺血-再灌注 保护作用 三磷酸腺苷酶 |
Protective Effect of Naloxone on Renal Ischemic-Reperfusion Injury in Rat |
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| Huang Lifang.Protective Effect of Naloxone on Renal Ischemic-Reperfusion Injury in Rat[J].China Pharmaceuticals,2011,20(19):11-12. |
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| Authors: | Huang Lifang |
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| Institution: | Huang Lifang(Department of Pharmacy,Zigong Fourth People's Hospital,Zigong,Sichuan,China 643000) |
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| Abstract: | Objective To investigate the protective effect of naloxone on renal injury caused by ischemic reperfusion in rat.Methods Using the rat model of renal ischemic-reperfusion injury,the influence of naloxone on malondialdehyde(MDA),superoxide dismutase(SOD),Na+-K+-ATP and Ca2+-ATP enzyme in renal tissues and the histopathological changes after renal ischemia were observed.Results After renal ischemic-reperfusion,plasma MDA levels were significantly increased,SOD activity was significantly reduced,renal Na+-K+-A... |
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| Keywords: | naloxone ischemic reperfusion protective function ATP enzyme free radical |
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