| 还原型谷胱甘肽治疗慢性铅中毒合并肝脏损害42例 |
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| 引用本文： | 张少俭. 还原型谷胱甘肽治疗慢性铅中毒合并肝脏损害42例[J]. 中国药业, 2011, 20(17): 63-64 |
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| 作者姓名： | 张少俭 |
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| 作者单位： | 陕西省宝鸡市妇幼保健院内科,陕西,宝鸡,721000 |
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| 摘 要： | 目的观察还原型谷胱甘肽(GSH)对慢性职业性铅中毒肝脏损害的肝功能改善作用。方法对42例慢性铅中毒合并肝脏损害患者,给予5%葡萄糖注射液250 mL+还原型谷胱甘肽2.4 g静脉滴注,1次/d,连用7 d为1个疗程;5%葡萄糖注射液500 mL+依地酸二钠钙1.0 g静脉滴注,1次/d,连用3 d,停4 d为1个疗程。每个疗程结束后测定血铅值,复查肝功能。结果 42例患者经1～3个疗程治疗后,肝功能全部恢复正常,血铅值均降至400μg/L以下。结论还原型谷胱甘肽治疗慢性铅中毒合并肝脏损害疗效确切,值得临床推广,还应作为解毒药在络合剂驱铅治疗时联合应用。
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| 关 键 词： | 还原型谷胱甘肽 慢性铅中毒 肝脏损害 保肝治疗 |
Reduced Glutathione in Treating Chronic Lead Poisoning Combined with Liver Injury in 42 Cases |
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| Zhang Shaojian. Reduced Glutathione in Treating Chronic Lead Poisoning Combined with Liver Injury in 42 Cases[J]. China Pharmaceuticals, 2011, 20(17): 63-64 |
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| Authors: | Zhang Shaojian |
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| Affiliation: | Zhang Shaojian(Department of Medicine,Baoji Municipal Women and Children Health Hospital,Baoji,Shaanxi,China 721000) |
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| Abstract: | Objective To survey the improving effect of reduced glutathione(GSH)on chronic occupational lead poisoning liver injury hepatocyte.Methods For the 42 patients suffering chronic lead poisoning liver injury,intravenous inject 250 mL of 5%glucose and 2.4 of GSH once per day,continuously 7 d for 1 course of treatment.Intravenous injecting 500 mL of 5%glucose and 1.0 of calcium sodium edentate once per day,continuously 3 d injection and 4 d without injection for 1 course of treatment.After every course of treatm... |
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| Keywords: | GSH chronic lead poisoning liver injury protecting silver therapy |
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