Microtubules-interfering agents restrict aryl hydrocarbon receptor-mediated CYP1A2 induction in primary cultures of human hepatocytes via c-jun-N-terminal kinase and glucocorticoid receptor |
| |
| Authors: | Vrzal Radim Daujat-Chavanieu Martine Pascussi Jean-Marc Ulrichova Jitka Maurel Patrick Dvorak Zdenek |
| |
| Affiliation: | Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic. |
| |
| Abstract: | |
| |
| Keywords: | AhR, aryl hydrocarbon receptor ARNT, aryl hydrocarbon receptor nuclear translocator CAR, constitutive androstane receptor CHX, cycloheximide CYP, cytochrome P450 ERK, extracellular-regulated protein kinase dimethylsulfoxide GAPDH, glyceraldehyde-3-phosphate dehydrogenase GR, glucocorticoid receptor HepG2, human hepatoma cells JNK, c-Jun -N-terminal kinase MAPK, mitogen-activated protein kinase MIAs, microtubule interfering agents MTs, microtubules PAHs, polycyclic aromatic hydrocarbons PXR, pregnane X receptor SP600125, an inhibitor of JNK (1,9-Pyrazoloanthrone) SOR, sorbitol TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin TAT, tyrosine aminotransferase |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
