Microtubules-interfering agents restrict aryl hydrocarbon receptor-mediated CYP1A2 induction in primary cultures of human hepatocytes via c-jun-N-terminal kinase and glucocorticoid receptor期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Microtubules-interfering agents restrict aryl hydrocarbon receptor-mediated CYP1A2 induction in primary cultures of human hepatocytes via c-jun-N-terminal kinase and glucocorticoid receptor

Authors:	Vrzal Radim Daujat-Chavanieu Martine Pascussi Jean-Marc Ulrichova Jitka Maurel Patrick Dvorak Zdenek

Institution:	Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic.

Abstract:

Keywords:	AhR aryl hydrocarbon receptor ARNT aryl hydrocarbon receptor nuclear translocator CAR constitutive androstane receptor CHX cycloheximide CYP cytochrome P450 ERK extracellular-regulated protein kinase dimethylsulfoxide GAPDH glyceraldehyde-3-phosphate dehydrogenase GR glucocorticoid receptor HepG2 human hepatoma cells JNK c-Jun -N-terminal kinase MAPK mitogen-activated protein kinase MIAs microtubule interfering agents MTs microtubules PAHs polycyclic aromatic hydrocarbons PXR pregnane X receptor SP600125 an inhibitor of JNK (1 9-Pyrazoloanthrone) SOR sorbitol TCDD 2 3 7 8-tetrachlorodibenzo-p-dioxin TAT tyrosine aminotransferase
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