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Case Report: Primary splenic non-Hodgkin's B cell lymphoma in a patient with chronic hepatitis C |
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| Authors: | TAKAYOSHI FUKUTOMI MARIE FUKUSHIMA YUICHI TANABE KAICHIRO HIROSHIGE HIDETOSHI ITASAKA TAKASHI MATSUMATA NORIKO KASAI KISAKU YOSHIDA JUNJI SUZUMIYA MASAHIRO KIKUCHI YUJI YUFU HIRONORI SAKAI JUNJI NISHIMURA HAJIME NAWATA |
| Institution: | *Department, of Internal Medicine, Kyushu University, Fukuoka, Japan;†Department, of Surgery and Fukuoka City Hospital, Kyushu University, Fukuoka, Japan;‡Radiology, Fukuoka City Hospital, Kyushu University, Fukuoka, Japan;§First Department of Pathology, Faculty of Medicine, Fukuoka University, Japan;#Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan |
| Abstract: | A case of primary splenic lymphoma in a patient with chronic hepatitis C is reported. A 69-year-old man with chronic hepatitis C was admitted to Fukuoka City Hospital for evaluation of an enlarging splenic tumour. In the spleen, ultrasonographic examination revealed a hypoechoic tumour and computed tomography demonstrated a non-enhancing low density area measuring 7 cm in diameter; coeliac angiography revealed a hypovascular tumour. Gallium scintigraphy showed uptake of the radioisotope in the splenic tumour. A splenectomy was performed and the morphological and immunohistochemical findings of this tumour were compatible with those of non-Hodgin's B cell lymphoma. Recently, cases of malignant B cell lymphoma associated with hepatitis C virus infection have been reported. Lymphotropism of hepatitis C virus may play a pathological role in the development of non-Hodgkin's lymphoma. We emphasize the importance of considering lymphoma in the differential diagnosis of extrahepatic disorders during the course of chronic hepatitis C virus infections. |
| Keywords: | hepatitis C virus non-Hodgkin's lymphoma |