血清视黄醇结合蛋白4与2型糖尿病颈动脉粥样硬化的关系

目的探讨血清视黄醇结合蛋白4（RBP4）水平与2型糖尿病（T2DM）颈动脉粥样硬化（AS）的关系。方法100例T2DM患者,分成AS组39例和无AS组61例。30例非糖尿病者为正常对照组。分别检测血清RBP4浓度、甲状腺素转运蛋白（TTR）、体质量指数、血压、血脂和糖化血红蛋白（HbA1c）等。结果T2DM组（AS组和无AS组）血清RBP4浓度及RBP4/TTR较正常对照组均明显升高;T2DM中AS组较无AS组RBP4/TTR明显升高,差异均有统计学意义（均P〈0.05）,但AS组和无AS组血清RBP4浓度的差异无统计学意义（P〉0.05）。多危险因素与T2DM颈动脉粥样硬化Logistic回归分析表明RBP4及RBP4/TTR是T2DM颈动脉粥样硬化的危险因素（b〉0,OR〉1,P〈0.1）。结论RBP4与T2DM密切相关,也是T2DM颈动脉粥样硬化发生的危险因素。

The Correlation Study of Serum Retinol Binding Protein 4 and Atherosclerosis in Type 2 Diabetes

Objective To evaluate the association of Retinol binding protein 4（RBP4） with carotid atherosclerosis in type 2 diabetes mellitus （T2DM）. Methods ELISA was used to detect the serum RBP4 level in 100 T2DM in 39 of which carotid atherosclerosis was observed and in the 30 controls, transthyretin （TTR） and other clinical index were also tested. Results Serum RBP4 level and RBP4/ TTR were significantly higher in T2DM with/without carotid atherosclerosis than that in the controls （P＆lt; 0.05）. Moreover, RBP4/TTR
was markedly increased in T2DM with carotid atherosclerosis than that in T2DM without carotid atherosclerosis （P〈0.05）. However, there was no difference in serum RBP4 level between T2DM with and without carotid atherosclerosis. Logistic regression analysis showed RBP4 and RBP4/TTR were the important risk factors for carotid atherosclerosis in T2DM （b〉0, OR〉1, P〈0.1）. Conclusion Serum RBP4 may be a novel risk factor for diabetes with atherosclerosis. Importantly, the RBP4/TTR ratio is more valuable than serum RBP4 concentration to used to evaluate risk factor for carotid atherosclerosis in T2DM.