| 鼻咽癌组织中COX-2与VEGF-C基因表达的研究 |
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| 引用本文： | 李建萍,张小清,罗雄,左克强,谢明.鼻咽癌组织中COX-2与VEGF-C基因表达的研究[J].湖南师范大学学报(医学版),2012,9(3):25-27,38. |
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| 作者姓名： | 李建萍 张小清 罗雄 左克强 谢明 |
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| 作者单位： | 1. 湘南学院基础医学部,湖南郴州,423000
2. 湘南学院基础医学部,湖南郴州423000;湘南学院附属医院病理科,湖南郴州423000 |
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| 摘 要： | 目的:研究环氧化酶-2(COX-2)和血管内皮生长因子(VEGF-C)在鼻咽癌组织中的表达及其临床意义。方法:采用逆转录-聚合酶链法(RT-PCR)检测32例鼻咽癌和11例癌旁鼻咽正常组织标本中COX-2mRNA与VEGF-C-mRNA的表达。结果:COX-2 mRNA与VEGF-CmRNA在鼻咽癌中的表达分别为68.7%和71.9%,显著高于癌旁鼻咽正常组织(P<0.01,P<0.005);在有淋巴结转移患者中COX-2 mRNA与VEGF-C-mRNA阳性表达均明显高于无淋巴结转移患者(P<0.05,P<0.01)。结论:COX-2与VEGF-C基因在鼻咽癌中组织的发生、发展、转移中发挥重要作用。
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| 关 键 词： | 鼻咽癌 环氧化酶-2 血管内皮生长因子-C RT-PCR |
Expression of COX-2 and VEGF-C in nasopharyngeal carcinoma |
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| Li Jianping
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Zhang Xiaoqing
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Luo Xiong
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Zuo Keqiang
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Xie Ming.Expression of COX-2 and VEGF-C in nasopharyngeal carcinoma[J].Journal of Hunan Normal University(Medical Science),2012,9(3):25-27,38. |
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| Authors: | Li Jianping Zhang Xiaoqing Luo Xiong Zuo Keqiang Xie Ming |
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| Institution: | (Department of Biochemistry of Basic Medical Dept,Xiangnan University,Chenzhou 423000,China) |
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| Abstract: | Objective To investigate the expression cyclooxygenase-2(COX-2) and vascular endothelial growth factor(VEGF-C) in nasopharyngeal carcinoma(NPC).Medthods RT-PCR were used to detect the expression of COX-2 mRNA and VEGF-C rnRNA in 32 cases of NPC and 11 cases of normal tissues.Results The expression of COX-2 mRNA were 68.7% and VEGF-C-mRNA were 71.9% respectively,both of them increased in cancer tissues compared to normal tissues significantly(P<0.05、P<0.005);COX-2rnRNA expression were correlated lymph node invasiveness of NPC(P<0.05);VEGF-C-mRNA were correlated lymph node invasiveness of NPC(P<0.01).Conclusion The COX-2 and VEGF-C gene may play an imporatant role in nasopharyngeal carcinoma. |
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| Keywords: | NPC COX-2 VEGF-C RT-PCR |
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