乌药醚内酯对肝损伤模型大鼠的保护作用

目的 考察不同剂量乌药醚内酯对大鼠肝损伤模型的保护作用。 方法 60只健康雄性SD大鼠随机均分为空白对照组、模型组、乌药醚内酯低、中、高剂量组及阳性药物对照组,除空白对照组外,其余5组采用四氯化碳腹腔注射建立肝损伤大鼠模型,造模期间各组给予相应的药物或等体积的水,造模6w后处死大鼠取血清,测ALT、AST、MDA含量及SOD、GSH-Px的活性,取肝脏组织染色切片观察病理变化。 结果 与模型组对比,乌药醚内酯各剂量组能降低模型大鼠血清ALT、AST且呈剂量依赖性；高剂量组还能显著升高模型大鼠血清SOD、GSH-Px活性,降低MDA含量,显著降低肝脏组织的病理变化评分。 结论 乌药醚内酯可能通过提高抗氧化能力来降低肝损伤模型大鼠的ALT和AST水平及肝脏病理变化。

Hepatoprotective Effects of the Linderane on Liver Injury Model of Rats

OBJECTIVE To investigate the hepatoprotective effects of different doses of Linderane on liver injury using rat model. METHODS Sixty healthy male SD rats were randomly divided into 6 groups, which were control group, model group, linderane low-dose, medium-dose, high-dose group and positive control group. In addition to the control group, the other 5 groups were established liver injury model by carbon tetrachloride intraperitoneal injection. Each group was given either corresponding drug or the same volume of water during modeling. All the rats were killed after 6 weeks, and then the activity of ALT, AST, SOD, GSH-Px and the contents of MDA in serum were measured. The liver tissue sections were stained in order to observe their pathological changes. RESULTS Compared with the model group, linderane could decrease the activity of serum ALT and AST in model rats in a dose-dependent manner. The high-dose group could significantly increase the activity of serum SOD and GSH-Px, decrease serum MDA content, and significantly reduce the score of pathological changes of liver tissue in model rats. CONCLUSION The linderane could improve the antioxidant capacity against the liver injury induced by CCl₄ in rats.