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Role of FDG-PET/CT in detecting lymphomatous bone marrow involvement in patients with newly diagnosed diffuse large B-cell lymphoma |
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| Authors: | Hong Junshik Lee Yukyung Park Yeonjeong Kim Seog Gyun Hwang Kyung Hoon Park Soon Ho Jeong Jihoon Kim Kyung-Hee Ahn Jeong Yeal Park Sanghui Park Jinny Lee Jae Hoon |
| Affiliation: | 1. Department of Internal Medicine, Gachon University Gil Hospital, Gachon University of Medicine and Science School of Medicine, Incheon, Republic of Korea 2. Department of Nuclear Medicine, Gachon University Gil Hospital, Gachon University of Medicine and Science School of Medicine, Incheon, Republic of Korea 3. Department of Laboratory Medicine, Gachon University Gil Hospital, Gachon University of Medicine and Science School of Medicine, Incheon, Republic of Korea 4. Department of Pathology, Gachon University Gil Hospital, Gachon University of Medicine and Science School of Medicine, Incheon, Republic of Korea |
| Abstract: | To evaluate the role of FDG-PET/CT in detecting bone marrow (BM) involvement, pre-treatment bilateral bone marrow biopsies (BMBs) and FDG-PET/CT scans of 89 patients with diffuse large B-cell lymphoma (DLBCL) treated with rituximab-CHOP were reviewed and analyzed. Fourteen patients (15.7%) had lymphomatous involvement based on BMB (BMB+), and 17 patients (19.1%) had the possibility of BM involvement on FDG-PET/CT (FDG-PET/CT+). Seventy-two patients (80.8%) had concordant results between BMB and FDG-PET/CT (seven patients were positive for both, and 65 patients were negative for both), but 17 patients (19.2%) had a discordant interpretation (seven patients were BMB+ and FDG-PET/CT-, and ten were BMB- and FDG-PET/CT+). Although BMB+ patients had an inferior 2-year EFS (37.0% vs. 79.8%, p? |
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