Gene therapy of established mesothelioma xenografts with recombinant p16INK4a adenovirus |
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Authors: | Frizelle S P Rubins J B Zhou J X Curiel D T Kratzke R A |
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Institution: | The Department of Medicine and Research Service, Minneapolis Veterans Affairs Medical Center, University of Minnesota Medical School, 55417, USA. |
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Abstract: | The absence of expression of the p16INK4a gene product is observed in virtually all mesothelioma tumors and cell lines, whereas wild-type pRB expression is maintained. We have examined the potential therapeutic role of re-expressing the p16INK4a gene product in mice with established human mesothelioma xenografts. Experiments using Adp16 treatments in mesothelioma xenografts demonstrated prolonged survival and potential cure following treatment with p16INK4a-based gene therapy. These results demonstrate that p16INK4a gene transfer may play a therapeutic role in the treatment of mesothelioma. |
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