Preparation and quality control of the [sm]-samarium maltolate complex as a lanthanide mobilization product in rats |
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Authors: | Naseri Zohreh Hakimi Amir Jalilian Amir R Nemati Kharat Ali Bahrami-Samani Ali Ghannadi-Maragheh Mohammad |
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Institution: | Inorganic Chemistry Department, Faculty of Sciences, Tehran University, Tehran, Iran. |
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Abstract: | Development of lanthanide detoxification agents and protocols is of great importance in management of overdoses. Due to safety of maltol as a detoxifying agent in metal overloads, it can be used as a lanthanide detoxifying agent. In order to demonstrate the biodistribution of final complex, (153)Sm]-samarium maltolate was prepared using Sm-153 chloride (radiochemical purity >99.9%; ITLC and specific activity). The stability of the labeled compound was determined in the final solution up to 24h as well as the partition coefficient. Biodistribution studies of Sm-153 chloride, (153)Sm]-samarium maltolate were carried out in wild-type rats comparing the critical organ uptakes. Comparative study for Sm(3+) cation and the labeled compound was conducted up to 48 h, demonstrating a more rapid wash out for the labeled compound. The effective and biological half lives of 2.3 h and 2.46h were calculated for the complex. The data suggest the detoxification property of maltol formulation for lanthanide overdoses. |
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Keywords: | Detoxification Maltolate Sm-153 Biodistribution Radiolabeling |
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