灯盏细辛治疗肺心病73例临床分析

目的：观察蛋白激酶C抑制剂灯盏细辛对肺心病患的治疗效果及其机制。方法：应用灯盏细辛每日40ml静脉点滴15d治疗30例肺心病患，同时与43例未用此药的肺心病患对照。观察治疗前后血清一氧化氮（NO）和内皮素－1（ET－1）的变化。结果：灯盏细辛治疗组总有效率达83％，明显高于对照组，治疗组肺心病患治疗后血清NO水平明显升高，ET－1水平明显降低。结论：灯盏细辛对于肺心病的治疗有较好的疗效，其机制可能是通过PKC信号转导途径调控NO和ET－1而起作用，值得临床推广应用。

Observation on the effect of breviscapine on treatment of chronic pulmonary heart disease

Objective To study the effect and mechanisms of breviscapine, a protein kinase C inhibiter,on treatment of chronic pulmonary heart dusease. Methods 40ml breviscapine were used to 30 patients with chronic pulmonary heart disease by intravenousdrip everyday and contrast with 43 patients with chronic pulmonary heart disease. The serum levels of nitrogen monoxide(NO) and endothelin-1(ET-1) of patients were detected pretherapy and post-treatment.Results The effective rate of treatment group was 83% and significant higher than that of contract group. The post-treatment serum levels of NO were significantly higher and ET-1's levels were significantly lower than that of pretherapy. Conclusion Breviscapine has better effect in therapy of patients with chronic pulmonary heart disease. The mechanism of it maybe through protein kinase C by modulating NO and ET-1.