| RP-HPLC法测定西尼地平有关物质 |
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| 引用本文： | 王世刚,顾攀. RP-HPLC法测定西尼地平有关物质[J]. 安徽医药, 2011, 15(10): 1224-1226 |
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| 作者姓名： | 王世刚 顾攀 |
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| 作者单位： | 1. 安徽省蚌埠市食品药品检验所,安徽,蚌埠,233000
2. 安徽省蚌埠丰原医药科技发展有限公司,安徽,蚌埠,233010 |
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| 摘 要： | 目的 建立西尼地平有关物质检测方法.方法 采用十八烷基硅烷键合硅胶柱,流动相为乙腈:0.025 mol·L-1磷酸二氢铵溶液:环己烷=60:39:1,柱温40℃,流速1.5 ml·min-1,检测波长为240 nm.结果 通过破坏性试验,用此条件检测,主峰和杂质峰均能很好的得到分离,不受干扰,专属性强,线性范围:1～...
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| 关 键 词： | 西尼地平有关物质 高效液相色谱法 测定 |
Determination of cilnidipine related substances by RP-HPLC |
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| WANG Shi-gang,GU Pan. Determination of cilnidipine related substances by RP-HPLC[J]. Anhui Medical and Pharmaceutical Journal, 2011, 15(10): 1224-1226 |
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| Authors: | WANG Shi-gang GU Pan |
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| Affiliation: | 1.Bengbu Institute for the Control of Food and Drug,Bengbu 233000,China; 2.Bengbu BBCA Medicine Science Development Co.,Ltd,Bengbu 233010,China) |
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| Abstract: | Aim To establish an RP-HPLC method for the determination of cilnidipine related substances.Methods The separation was performed on octadecylsilane chemically boned silica column.The mobile phase was composed of acetonitrile∶0.025 mol·L-1ammonium dihydrogen phosphate solution∶cyclohexane（60∶ 39∶ 1）.Column temperature was 40℃,and the flow rate was 1.5 ml·min-1.The detection was carried out with UV detector at 240 nm.Results Through intensity destructive test under this detection,main peak and impurity peak were well separated,with not being disturbed.Specificity calibration curves were linear within 1～16 mg·L-1（r=0.999 992）.RSD was 0.42%（n=6）.Conclusion The test shows that this method is suitable for the determination of cilnidipine related substances. |
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| Keywords: | cilnidipine related substances HPLC determination |
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