| 高效液相色谱法测定对乙酰氨基酚颗粒的含量 |
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| 引用本文： | 邵超,沈黎. 高效液相色谱法测定对乙酰氨基酚颗粒的含量[J]. 安徽医药, 2011, 15(10): 1218-1219 |
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| 作者姓名： | 邵超 沈黎 |
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| 作者单位： | 安徽省阜阳市食品药品检验所,安徽,阜阳,236015;安徽省阜阳市食品药品检验所,安徽,阜阳,236015 |
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| 摘 要： | 目的 建立对乙酰氨基酚颗粒含量的高效液相测定方法.方法 色谱柱为Waters Sunfire CI8 柱(4.6 mm×150 mm,5 μm),流动相为磷酸盐缓冲液(pH4.5)-甲醇(80:20),流速为1.0 ml·min-1,检测波长为254 nm,柱温为30℃.结果 对乙酰氨基酚在0.05～0.40 g·L...
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| 关 键 词： | 高效液相色谱法 对乙酰氨基酚颗粒 含量测定 |
Determination of paracetamol granules by HPLC |
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| SHAO Chao,SHEN Li. Determination of paracetamol granules by HPLC[J]. Anhui Medical and Pharmaceutical Journal, 2011, 15(10): 1218-1219 |
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| Authors: | SHAO Chao SHEN Li |
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| Affiliation: | (Institute for Food and Drug Control,Fuyang,Anhui 236015,China) |
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| Abstract: | Aim To establish an HPLC method for the determination of paracetamol granules.Methods Waters Sunfire C_I8 column（4.6 mm×150 mm,5 μm）was used with phosphate buffering solution（pH 4.5）-methanol（80∶20）as the mobile phase.The flow rate was 1.0 mL·min-1.The UV detection wavelength was 254 nm,and the column temperature was 30℃.Results The calibration curve of paracetamol was linear in the range of 0.05~0.40 g·L-1（r=1.0）.The average recovery（n=5）was 99.9% and RSD was 0.59%.Conclusion The method is accurate,reliable,and can be used for the determination of paracetamol granules. |
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| Keywords: | HPLC paracetamol granules determination |
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