社区获得性肺炎住院患者血清除降钙素原与肺炎严重程度和预后的关系

目的 考察血清降钙素原水平与社区获得性肺炎(CAP)住院患者严重程度和预后的关系.方法 回顾性分析住院患者数据库中,2009年7月～2010年7月收治的CAP患者的临床资料.结果 324例CAP住院患者中,212例(182例普通CAP、22例重症肺炎和14例死亡病例)纳入本研究.212例患者入院时平均血降钙素原为(...

Values of serum procalcitonin in predicting severity and prognosis of community-acquired pneumonia in-patients

Aim To investigate the relationship of serum procalcitonin to severity and prognosis of community-acquired pneumonia in-patients.Methods Retrospective analysis was made of community-acquired pneumonia in-patients admitted to hospital from July 2009 to July 2010.Results Among 324 cases of community-acquired pneumonia admitted,248 cases were included for analysis.The mean levels of serum procalcitonin,neutrophil number,average duration of intravenous antibiotic therapy,average hospital stay,PSI scale and CURB-65 score were（0.22±0.34） μg·L-1,（8.92±2.47）×109 ·L-1,（8.7±2.6）days,（9.2±2.4）days,67.8±33.5,2.12±0.45.The correlation indices of serum procalcitonin to PSI and CURB-65 score and duration of intravenous antibiotic therapy,average hospital stay were 0.845,0.22,0.404 and 0.443,respectively.The mean procalcitonin levels of severe CAP and deaths were（5.87±2.83） μg·L-1 and（2.42±1.28） μg·L-1,respectively.The sensitivity and specificity of serum procalcitonin more than 0.5 μg·L-1 on admission were 0.714 and 0.844 in predicting death.Conclusion The serum level of procalcitonin on admission is correlated with severity of community-acquired pneumonia in-patients,and PCT≥0.335 μg·L-1 may indicate poorer prognosis.